Kyowa Hakko Kirin Co., Limited

Dai Nippon Printing Co., Ltd.

Fujitsu Toshiba Mobile Communications Limited

Kazuhiro Masuda

Kazuyasu Nakamura

Kenya Shitara

Akiko Furuya

Hiroshi Ando

Eisuke Mekada

Yuka Sasaki

Shingo Miyamoto

Ryo Iwamoto

Kumiko Takahashi

Rinpei Niwa

Tsuguo Kubota

Katsuyuki Oshima

Tatsuya Kita

Jiro Onishi

Makoto Hashiba

Sayaka Hori

Tomoaki Nakagawa

Masahiro Yuki

Kazutoshi Awano

Kenji Sakamoto

Tsuaki Odaka

Chie Fujimoto

An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell. The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.

Anti-CD4 antibody

Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor

A mobile communication apparatus configured to communicate with an opposite communication device is provided. The mobile communication apparatus includes a transceiver configured to receive an incoming signal sent from the opposite communication device. The transceiver is configured to produce an interrupt signal upon receiving the incoming signal. The mobile communication apparatus includes a first memory device and a non-volatile second memory device. The mobile communication apparatus includes a controller connected to the transceiver, the first memory device and the second memory device. The controller is configured to perform garbage collection of the second memory device, to load data stored in one of the first memory device and the second memory device into another of the first memory device and the second memory device, to access the first memory device if the transceiver produces the interrupt signal.

Apparatus and method for mobile communication by using non-volatile memory device

A protective layer transfer film and an intermediate transfer recording medium are disclosed, which can impart excellent fastness properties (durability), particularly excellent fastness to plasticizers and abrasion, to an image formed on an object. The protective layer transfer film includes a substrate film and a transfer part provided separably on the substrate film. The transfer part includes at least a plasticizer-resistant layer and a receptive layer on which an image is to be formed. The intermediate transfer recording medium is adapted for the transfer of the transfer part onto an object after the formation of an image on the receptive layer. The plasticizer-resistant layer is formed of an acrylic copolymer resin.

Protective layer transfer film, intermediate recording medium and printed matter

The present invention provides a protective layer transfer sheet, which has excellent folding resistance, plasticizer resistance, scratch resistance, transparency, layer transferability and other properties, and a print using the same. The protective layer transfer sheet comprises: a substrate sheet; and a thermally transferable resin layer provided separably on at least a part of one side of the substrate sheet. The thermally transferable resin layer comprises at least a thermally transferable protective layer and a heat-sensitive adhesive resin layer stacked in that order from the substrate sheet side. The thermally transferable protective layer comprises a layer comprising submicron particles of a layered inorganic material dispersed in a binder resin. The print is formed using the thermally transferable protective layer.

Protective layer transfer sheet and printed product

The present invention provides a protective layer thermal transfer sheet in which: a protective layer having a thermal transferring property is placed on at least one portion of one of the faces of a substrate sheet and the protective layer is formed by successively laminating at least a peeling layer, a plasticizer resistant layer and a heat adhesive resin layer on the substrate sheet, and in this structure, the heat adhesive resin layer is made from a polyester-urethane resin; and a printed article with the protective layer transferred thereto.

Protective layer thermal transfer sheet and printed article with protective layer

An image formation method and a thermal transfer sheet for use in the image formation method are provided. According to the image formation method and the thermal transfer sheet, an intermediate transfer recording medium comprising a substrate film and a transfer part, comprising at least a receptive layer, provided separably on the substrate film is used, and, at the time of the transfer of the transfer part in the intermediate transfer recording medium onto an object, the transfer of the transfer part onto the object in its nontransfer region, onto which the transfer part should not be transferred, can be avoided without installing any special ancillary tool on an image forming apparatus. In the method for image formation, a thermal transfer sheet comprising a substrate and at least a peel-off layer provided on the substrate is provided. Further, an intermediate transfer recording medium comprising a substrate film and a transfer part, comprising at least a receptive layer, provided separably on the substrate film is provided. The thermal transfer sheet and the intermediate transfer recording medium are put on top of each other so that the peel-off layer in the thermal transfer sheet is brought into contact with the transfer part in the intermediate transfer recording medium. The assembly is heated to remove the transfer part in its predetermined region from the intermediate transfer recording medium. The transfer part is then retransferred from the intermediate transfer recording medium onto an object. That is, the transfer part in its predetermined region in the intermediate transfer recording medium is transferred onto the thermal transfer sheet side provided with the peel-off layer and is separated from the intermediate transfer recording medium side.

Thermal transfer sheet, method for image formation, method for image-formed object formation, and image-formed object

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Tokyo, Japan

Kazuhiro Masuda