Other

Taiho Pharmaceutical Company Limited

Nihon New Chrome Co., Ltd.

Ykk Snap Fasteners Japan Co., Ltd.

Kazuhiro Kitagawa

Tetsuji Asao

Shozo Yamada

Kenji Hasegawa

Shigeo Okajima

Kazuhiko Shigeno

Kazuya Urata

Mamoru Kiniwa

Yukio Ogawa

Toshiyuki Hosoya

Shin-ichi Inoue

The present invention relates to a Cu&#x2014;Sn&#x2014;O alloy plating having an oxygen content of 0.3 to 50 at %, a copper content of 20 to 80 at %, and a tin content of 10 to 70 at % in the plating. The present invention provides a copper tin alloy plating that has excellent plating adhesion and disengaging force stability and particularly a Cu&#x2014;Sn&#x2014;O alloy plating that has a blackish color tone without containing any controlled substances.

Copper-tin-oxygen alloy plating

A method of manufacturing substance GM-95 having general formula &lsqb;I&rsqb;, comprising (a) deprotecting a macrocyclic compound having general formula &lsqb;II&rsqb; (wherein, R 's are the same or different and each represents a lower alkyl group, and R represents a thiol protecting group) by removing acetal protecting groups (the R 's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula &lsqb;III&rsqb; (wherein, R is as mentioned above) by removing the thiol protecting group (R ) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.

Process for preparing substance GM-95

This invention provides a compound having both IL-4 production inhibitory activity and PDE (IV) inhibitory activity, represented by formula (I):

Benzimidazole derivatives and pharmacologically acceptable salts thereof

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Saitama, Japan

Kazuhiro Kitagawa