Kowa Company Limited

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Kazuhiro Kamiya

Toshihito Mori

Isamu Watanabe

Takeo Deushi

Akio Iwasaki

Masahito Nakayama

Toshimi Mizoguchi

Hisakatsu Ito

Takashi Yamaguchi

Takeshi Oda

Takafumi Kunieda

Hisakatsu Itoh

Takahiro Torii

Hamao Umezawa

Sumio Umezawa

Tsutomu Tsuchiya

Masami Shiratsuchi

Masahoto Nakayama

Azoxy compounds

An aminoglycoside compound represented by the following formula (I) ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom, and the other represents a methyl group,

Aminoglycoside compounds, processes for production thereof, and

An aminoglycoside compound represented by the following formula (1) ##STR1## wherein R.sub.1 and R.sub.2 are different from each other and each represents a hydrogen atom or a methyl group,

Aminoglycoside compounds

A compound of the following formula ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3 represents H or CH.sub.3, R.sub.4 represents H or C.sub.2 -C.sub.4 acyl substituted at the 2-, 3- or 4-position by an amino group, and Y represents ##STR2## provided that R.sub.1 and R.sub.2 are not CH.sub.3 at the same time, and an acid addition salt thereof; and a process for the production thereof.

2'-N-.beta.-Lysyl) aminoglycosides

An aminoglycoside represented by the following formula (1) ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom or an aminoacyl group, R.sub.4 represents a hydrogen atom or a hydroxyl or methoxy group, and R.sub.5 represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable acid addition salt thereof, a process for the production thereof and a pharmaceutical use thereof.

2'-Deamino aminoglycosides and composition thereof

An aminoglycoside compound of the following formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom and the other, a methyl group, R.sub.3 represents a hydrogen atom or an amino acyl group having 2 to 5 carbon atoms, R.sub.4 represents a lower alkyl group substituted by one or two substituents selected from the class consisting of hydroxy and amino groups, or a hexopyranosyl group whose hydroxy groups may be substituted by amino groups, and a pharmaceutically acceptable acid addition salt thereof; and an antibiotic composition comprising said compound and its pharmaceutically acceptable acid addition salt.

Aminoglycosides and use thereof

Novel antibiotics of the following structure ##STR1## wherein R represents a moiety selected from the group consisting of hydrogen, --COCH.sub.2 NH.sub.2, --COCH.sub.2 NHCONH.sub.2 and --COCH.sub.2 NHCHO; process for preparation thereof; and biologically pure culture for use therein.

Biologically pure culture

A compound of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are different and each represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom, or a glycyl group which may be substituted, and the symbol  between the carbon atoms at the 5- and 6- positions represents a single or double bond, and an acid addition salt thereof; and its antibiotic use.

Ka-6606 Aminoglycosides antibiotics and compositions thereof

An antibiotic substance KA-7038 selected from the group consisting of the compounds having formulae I to VII described in claim 1, mixtures thereof and acid addition salts thereof; an antibiotic composition composed of (i) antibiotically effective amount of aforesaid antibiotic substance KA-7038, and (ii) a pharmaceutically acceptable diluent or carrier. The antibiotic substance KA-7038 can be produced by cultivating an antibiotic substance KA-7038-producing strain belonging to genus Streptomyces, for example Streptomyces sp. KC-7038, and isolating the antibiotic substance KA-7038 from the culture broth.

Process for preparation of antibiotics and biologically pure culture for

Novel antibiotics, process for preparation thereof and biologically pure

Antibiotic KA-7038 and compositions containing same

Antibiotics of the KA-6606 series and pharmaceutical compositions thereof

Growing community of inventors

Higashimurayama, Japan

Kazuhiro Kamiya