Respivert Limited

Pulmocide Limited

Topivert Pharma Limited

Plumocide Limited

Kazuhiro Ito

Stuart Thomas Onions

Peter Strong

Peter John Murray

John King-Underwood

Catherine Elisabeth Charron

Mihiro Sunose

Thomas Christopher Colley

Jonathan Gareth Williams

Garth Rapeport

Alistair Ian Longshaw

William Garth Rapeport

Euan Alexander Fraser Fordyce

Simon Fraser Hunt

Vladimir Sherbukhin

Daniel William Brookes

Frederick Arthur Brookfield

Christopher John Brown

George Hardy

Matthew Stephen Coates

David Michel Adrien Taddei

Alex Herman Copmans

Simon Christopher Hirst

Rudy Broeckx

Walter Filliers

Matthew McConville

Stephen Thom

Matthew Colin Thor Fyfe

Lorna Duffy

Kevin Joly

Daniel Hamza

Hayley Tegan Angela Watson

David Michael Adrien Taddei

Lindsey Cass

Jennifer Claire Thomas

Euan Alexander Fordyce

Claire Anne Marie Cariou

Robert Fenton

Matthew Mcconville

Scott Crowe

Keith Ray

Stephen Malcolm Thom

Alex Copmans

Catherine Elizabeth Charron

A combination therapy including one or more compounds of formula (I): wherein R represents hydrogen, halo, cyano, Chaloalkyl, Chaloalkoxy, or SONRR, Rand Rindependently represent hydrogen or halo; Rrepresents hydrogen, halo, cyano, Calkyl, Calkoxy, or Chaloalkoxy; Rrepresents halo, cyano, Calkyl, or Chydroxyalkyl; Rrepresents hydrogen or Calkyl; X represents CH or N; Y represents N or CH which carbon atom may optionally be substituted by R, Ror R; Rand Rindependently represent hydrogen or Calkyl; or a pharmaceutically acceptable salt thereof; and a second or further active ingredient.

Process for preparing a compound useful to treat mycoses

A process for preparing a compound of formula (II): includes reacting a compound of formula (VIII): with a compound of formula (XIV): 

This invention relates to compounds which are used in the preparation of the compound of formula (I).

Compounds which are used in the preparation of the compound of formula (I)

A process for preparing a compound of formula (II):  includes reacting a compound of formula (VIII):  with a compound of formula (XIV): 

There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors

This invention relates to compounds which are used in the preparation of the compound of formula (II).

Compounds which are used in the preparation of the compound of formula (II)

There is provided a compound of formula (I) which is an inhibitor of the family of p38 mitogen-activated protein kinase enzymes, and to its use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as asthma and COPD.

1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-i-yl) ureas as P38 mapkinase inhibitors

A process for preparing a compound of formula (I): includes reacting a compound of formula (II): with a compound of formula (III): 

There are provided 5,6-dihydro-4H-dithieno[3,2-b:2',3&#x2032;-d]azepine derivatives(as defined in the disclosure) which are useful in the treatment of RSV infection and for the prevention of disease associated with RSV infection.

Compounds

The invention relates to aqueous suspension formulations of compounds, as defined in the specification and as represented by the compound of formula (I): and to their use in therapy.

Aqueous suspension formulation comprising 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro-phenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl) or a pharmaceutically acceptable salt thereof

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (I)). 

5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

A compound of formula (II): or a compound of formula (IV): or a compound of formula (XX): is useful in the treatment of mycoses.

Compound useful to treat mycoses

A process for preparing a compound of formula (I): or a pharmaceutically acceptable salt thereof includes reacting a compound of formula (6): (wherein R is H) with 2-aminocyclohexanol or a salt thereof.

Process for preparing 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro-phenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl) benzamide or a pharmaceutically acceptable salt thereof

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London, United Kingdom

Kazuhiro Ito