Tanabe Seiyaku Company, Limited

Kazuhiro Ishii

Masaaki Matsuo

Hiroshi Wada

Nobuchika Tsumagari

Mikio Matsumoto

A naphthalene derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkyl or phenyl-lower alkyl; or R.sup.1 and R.sup.2 are combined together to form lower alkylene; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration, and a method of preparation thereof are disclosed. Said naphthalene derivative is useful as a chiral reagent for determining the optical purity of an optically active compound containing within its molecule at least one functional group selected from hydroxy, amino and imino groups.

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Nara, Japan

Kazuhiro Ishii