Yoshitomi Pharmaceutical Industries, Ltd.

Kazuhiro Goto

Takanori Oe

Yutaka Maruyama

Masao Hisadome

Minoru Moriwaki

Osamu Yaoka

Mineo Tsuruda

Michio Nakanishi

Kazumi Saeki

Hiroshi Yasuda

Masami Shiroki

Toshihiro Kobayakawa

Tomohiko Munakata

Michio Terazawa

Kiyoteru Ikegami

Therapeutic agent for hypertension

Bis-(aminoalkoxy)-phenyl, pyridyl ketones, and use as immunological

Heterocyclic-substituted oxoalkanoic acid derivatives

A method of treating rheumatism which comprises administration of 9-chloro-7-(1H-tetrazol-5-yl)-5-oxo-5H-[1H]benzopyrano[2,3-b]pyridine, and its salt and its hydrate.

Method for treatment of rheumatism

A heterocyclic compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxycarbonyl, formyl, nitroso, acyl, phenacyl, aralkyl, .alpha.-(benzyloxycarbonyl)benzyl or .alpha.-carboxybenzyl; each of R.sup.2 and R.sup.3 is hydrogen, C.sub.1-4 alkyl or aryl; and all of R.sup.4, R.sup.5 and R.sup.6 are hydrogens, or both R.sup.1 and R.sup.6, and R.sup.4 and R.sup.5 together form single bonds; in which definitions the term 'acyl', 'phenacyl', 'aralkyl' or 'aryl' means that it may be substituted by at least one substituent at any position(s) on the aromatic nucleus, each substituent being independently selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxyl, phenyl, nitro, trifluoromethyl, methylthio, methanesulfonyl and methylenedioxy. Such compounds are useful as drugs for treating immune diseases.

Imidazo[2',1':2,3]-thiazolo[5,4-c]pyridines and composition thereof for

Penicillamine compounds of the formula: ##STR1## and of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, A and B are as defined hereinafter, and pharmaceutically acceptable acid addition salts thereof are disclosed. II are the products of hydrolysis or alcoholysis of I, and I are in turn the products of dehydration of II or alcohol removal form II. I and II are useful for the treatment of rheumatoid arthritis.

Penicillamine compounds

Pharmaceutical compositions containing 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine hydrochloride and a method of using such compositions in treatment of liver dysfunction in mammals are disclosed.

Treatment of liver dysfunction with

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Nakatsu, Japan

Kazuhiro Goto