Fuji Photo Film Company, Limited

Fujifilm Corporation

Schering Aktiengesellschaft

Kazuhiro Aikawa

Keiji Mihayashi

Takashi Tamura

Hiroyuki Hirai

Kozo Aoki

Hiroshi Kitaguchi

Masayuki Kawakami

Kazunobu Takahashi

Hirohiko Tsuzuki

Akiko Matsuura

Yongzhe Yan

Yoshihiro Fujita

Akira Abe

Junji Nishigaki

Masahiko Taniguchi

Kai Licha

Atsushi Hirai

Hidenobu Kuniyoshi

Toshio Koshimizu

Takehiro Kasahara

Kazuya Takeuchi

Hirohiko Kato

Hiroaki Eguchi

Makoto Kato

Natsuko Tsuda

Christin Perlitz

Takashi Matsui

A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein Rto Rrepresent an alkyl group or alkenyl group; Xand Xrepresent a single bond, &#x2014;O&#x2014;, or &#x2014;N(Z)- (Zrepresents hydrogen atom, or an alkyl group); Xto Xrepresent &#x2014;O&#x2014;, or &#x2014;N(Z)- (Zrepresents hydrogen atom, or an alkyl group); n represents an integer of 1 to 10; and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom, fluorine atom and sulfur atom. 

Higher fatty acid triester and amide derivative having diethylenetriamine-type metal chelate structure

The compound represented by general formula (I) below: wherein Rrepresents hydrogen atom or methyl group; X represents &#x2014;O(C&#x2550;O)&#x2014; or the like; and R represents hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or the like, and a polymer obtained by polymerizing a polymeric compound comprising the compound, which are useful for manufacturing hydrophilic polymer materials of high biocompatibility.

Biocompatible polymeric compound, biocompatible polymer and polymer particles

A steroid ester compound of a terminally-fluorinated alkyl fatty acid, a steroid compound having bis(trifluoromethyl)phenyl group, a phosphatidylserine compound having a terminally-fluorinated alkyl group, a glyceride compound having bis(trifluoromethyl phenyl group, or a glyceride compound having a terminally-fluorinated alkyl group. A vascular lesion can be selectively imaged by using a contrast medium comprising a liposome containing said compound or a salt thereof.

Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound

A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R, Rand Rindependently represent an alkyl group or an alkenyl group having 8 to 25 carbon atoms; X represents &#x2014;O&#x2014;, or &#x2014;N(Z)&#x2014; (Z represents hydrogen atom, or an alkyl group having 1 to 3 carbon atoms); and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom and sulfur atom; Ch represents a functional group represented by the following general formula (II), and in the general formula (II), any one of the hydrogen atom H, H, H, H, H, and His substituted with L. 

Higher fatty acid triester compound having diethylenetriamine-type metal chelate structure

A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, and Rrepresent a C-Calkyl group or the like; R, R, R, R, R, R, R, and Rrepresent a hydrogen atom, a C-Calkyl group, an aryl group or the like; Xand Xrepresent a C-Calkyl group or an aryl group and Xand Xin total have 0 to 4 carboxyl groups; m, m, and mrepresents 0 or 1; Lto Lindependently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

Near infrared fluorescent contrast agent and method for fluorescence imaging

A compound represented by the following general formula (IA) or a salt thereof: wherein Arrepresents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Arrepresents an aryl group having at least one iodine atom as a substituent; Land Lindependently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; Lrepresents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when Lis a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

Glycerol ester derivative

A carrier for cell culture comprising a carrier having a cationic group and polypeptide-modified portions formed on a surface of the carrier in a sea-island structure, and a carrier for cell culture comprising a water-containing gel comprising alginic acid, wherein a surface of the carrier is coated with collagen, and wherein the collagen is bound to a surface of the water-containing gel by means of chitosan.

Carrier for cell culture

A compound represented by the following general formula (I) or a salt thereof: wherein Arand Arindependently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; Land Lindependently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents &#x2014;CH(OH)&#x2014; or &#x2014;CO&#x2014;, which is suitable for an iodine-containing contrast medium containing liposomes.

1,3-glyceride compound having two iodophenyl groups

A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a vascular disease and the like.

Liposome containing hydrophobic iodine compound

A method for detaching a carrier for cell culture from cultured cells formed on a surface of said carrier, which includes the step of bringing the carrier for cell culture into contact with a compound represented by the following formula (I) or a polyphosphoric acid or a salt thereof: MOP-L-POM wherein Lrepresents a divalent bridging group; and M represents a hydrogen atom or a cation. The carrier preferably includes a calcium alginate layer and a cell adhesion gel layer.

Method for cell culture

A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component:R&#x2014;CO&#x2014;Rwherein Rrepresents a substituted or unsubstituted 2,3,5-triiodophenyl group or a substituted or unsubstituted 3,4,5-triiodophenyl group; and Rrepresents a hydrocarbon group having 10 or more carbon atoms, and an X-ray contrast medium, which comprises said liposome which is used for radiography of a vascular disease.

Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome

Benzimidazole compounds and drugs containing the same

Benzimidazole compounds

Benzimidazole compounds represented by the formula set out below and analogs thereof, wherein Y represents a single bond or sulfur atom; Z represents oxygen atom, sulfur atom, or N&mdash;R,; R,and R,independently represent hydrogen, a halogen atom, alkyl group or other; R,and R,independently represent hydrogen, alkyl group, acyl group or other; n and m independently represent an integer of 1, 2, or 3; and L represents a linking group such as C,alkylene group or an alkylene group containing one or more phenylene groups or ether groups. The compounds are useful as an active ingredient of a medicament such as a preventive and therapeutic medicament for hyperlipemia or arterial sclerosis.

Growing community of inventors

Kanagawa, Japan

Kazuhiro Aikawa