Otsuka Pharmaceutical Factory, Inc.

Other

Otsuka Pharmaceutical Company, Limited

Kazuhiko Tsutsumi

Yoshihiko Tsuda

Yasuhide Inoue

Yasuo Shoji

Kazuyoshi Miyata

Yasuhisa Kurogi

Chieko Naba

Eiji Uesaka

Kayoko Shinomiya

Atsushi Shima

Takashi Sakamoto

Masatoshi Inai

Fumio Shimizu

Tetsuhiko Shirasaka

Shizuo Nakamura

Takeshi Iwamoto

Mitsuru Hirohashi

Yoshihito Yamamoto

Setsuro Fujii, Deceased

Naosumi Kinoshita

Chieko Yoshida

Tagui Sugimoto

Weidong Yin

By Shinichiro Fujii, Successor

By Keiko Fujii, Successor

By Kaoruko Takada, Successor

Yauso Shoji

The present invention provides a pharmaceutical composition for treating diabetes containing 4-diethoxyphosphinoylmethyl-N-(4-bromo-2-cyanophenyl)benzamide, particularly a pharmaceutical composition for treating diabetes that exhibits excellent effects for treating type II diabetes and the prevention of diabetic complications.

Compositions for treating diabetes

The present invention provides an agent for preventing and curing fatty liver containing, as the effective ingredient compound, a carboxylic acid amide derivative represented by the general formula (1),

Agent for preventing and curing fatty liver and method for curing thereof

The present invention provides an agent for preventing and treating cataract comprising, as an active ingredient, a carboxylic acid amide derivative represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X are as defined above. The present invention has a marked preventive and therapeutic effect on the cataract belonging to various classifications and particularly on the diabetic cataract.

Composition for preventing and treating cataract

Phosphonic diester derivatives

The invention provides a phosphonic diester derivative of the formula: ##STR1## wherein the variables are as defined in the specification. The derivative of the invention has excellent hypolipidemic and hypoglycemic activities and little side effects and hence is useful as therapeutic and prophylactic agents for hyperlipidemic diseases and diabetes and as a therapeutic agent for cataract.

Novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, having the activities for inhibiting bone calcium absorption, for lowering the blood level of calcium, as analgesics, for inhibiting secretion of the gastric juice. Pharmaceutical composition can be prepared by formulating, at least one of the novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, together with a proteolytic enzyme inhibitors and/or pharmaceutically acceptable acids. The pharmaceutical composition are quite effective as agents for curing hypercalcemia, for curing Peget's disease, for curing osteoporosis, analgetic agent, anti-ulcerative agent and the like.

Polypeptide derivatives and calcium metabolism improving agent

A pharmaceutical composition for treating hyperlipidemia containing, as the active ingredient, at least one carboxamide compounds represented by the formula (1) which possess excellent activities in lowering serum lipid, as well as having low toxicity with high safety. Said carboxamide compounds represented by the formula (1) are known compounds developed by the present inventors, but the pharmacological activities for treating hyperlipidemia have not been found yet.

Method for treating hyperlipidemia

Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyceridemia, hyperphospholipidemia, hyperlipacidemia, and the like.

Carboxamide compounds, processes for preparing the same and a

Growing community of inventors

Tokushima, Japan

Kazuhiko Tsutsumi