Mitsui Chemicals, Inc.

Kazuhiko Togashi

Tomoyuki Ando

Hironori Komatsu

Toshihiro Oikawa

Atsushi Sakuma

Hiroki Ishibashi

Yasushi Fukuiri

Toshifumi Yamaki

Hideki Umetani

Hitoki Miyake

Haruki Mori

Tsuneji Suzuki

Hajime Iizuka

Tsuyoshi Inoue

Akiyoshi Kai

Takeshi Nakamura

Takashi Sato

Junichi Mohri

Kohichi Kawai

Akihiro Oyabe

Hiroyuki Yamashita

A novel gluconate dehydratase derived fromand a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

Gluconate dehydratase

A novel method has been found to produce 2,2'-anhydro-1-(&#x3b2;-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2&#x2032;-anhydro-1-(&#x3b2;-L-arabinofuranosyl)thymine. A novel method has been further found to L-2&#x2032;-deoxyribose derivatives as a useful synthetic intermediate through L-2,2&#x2032;-anhydro-5,6-dihydrocyclouridine derivative. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now.

L-nucleic acid derivatives and process for the synthesis thereof

Preparation of antiarrhythmic agents containing novel anilide derivatives represented by the following formula as active ingredient provides a new type of antiarrhythmic agent of highly safe and effective, without effects on cardiac function.

Anilide derivatives and antiarrhythmic agents containing the same

Growing community of inventors

Sodegaura, Japan

Kazuhiko Togashi