Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Kazuhiko Take

Youichi Shiokawa

Shinji Shigenaga

Kazunori Tsubaki

Nobukiyo Konishi

Kazuo Okumura

Hidenori Azami

Yoshiteru Eikyu

Kazuo Nakai

Ikuo Ueda

Hiroyuki Kaizawa

Ryushi Seo

Takashi Manabe

Tadashi Terasaka

Eiji Kawaminami

Kazuyuki Sakamoto

Takatoshi Kanayama

Hiromichi Itani

Masataka Morita

Yuta Fukuda

Yutaka Kondoh

Kazuyuki Kuramoto

Tatsuhisa Takahashi

Junya Ishida

Hiroshi Matsuda

Hiroshi Miyake

Takeshi Kato

Masaaki Matsuo

Natsuko Kayakiri

Kiyoshi Taniguchi

Chiyoshi Kasahara

Masanobu Nagano

Masaki Tomishima

Norihiro Igari

Hiroshi Sasaki

A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula:  In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or &#x2014;(CRR)&#x2014;; n is 1, 2, 3, or 4; Rand Rare hydrogen, etc.; Yto Yare each CRor N; each Ris hydrogen, etc.; Rand Rare hydrogen, etc.; m is 1, 2, or 3; Ris hydrogen, etc.; and Ris an optically substituted lower alkyl, etc.

Substituted amide compound

A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or &#x2014;(CRR)&#x2014;; n is 1, 2, 3, or 4; Rand Rare hydrogen, etc.; Yto Yare each CRor N; each Ris hydrogen, etc.; Rand Rare hydrogen, etc.; m is 1, 2, or 3; Ris hydrogen, etc.; and Ris an optionally substituted lower alkyl, etc.

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

A compound of the formula (I): in which Z, R , R , R , R , R , R , R and R are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

Benzhydryl derivatives

A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.

Pyridine compounds and their pharmaceutical use

Piperazine derivatives as tachykinin antagonists

This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc.,

Ethanolamine derivatives having sympathomimetic and anti-pollakiuria

The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.

Substituted-amine compound and a process for the preparation thereof

Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s)

Substituted-acetamide compound and a process for the preparation thereof

Compounds of the formula ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),

Novel substituted-acetamide compound and a process for the preparation

The present invention relates to imidazopyridine compounds of the formula: ##STR1## wherein R.sup.1 is lower alkynyl or lower alkynyloxy(lower)-alkyl,

Imidazopyridine compounds useful in the treatment of ulcers

Certain imidazo[1,2-a]heterocyclic compounds useful in the treatment of ulcers are provided.

Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers

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Tondabayashi, Japan

Kazuhiko Take