Japan Tobacco Inc.

Kazuhiko Sakuma

Junichi Haruta

Yoshihiro Watanabe

Itsuo Uchida

Katsuyoshi Hara

Akihiro Yasuda

An amide compound of the formula (I):&#x2003;wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R, R, Rand Rare H, hydroxy and the like, Ris H, alkyl and the like, m is an integer of 0-6, Ris an optionally substituted aryl and the like, and Ris H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-&#x3b1;, GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

Amide compounds and use of the same

Amide compounds and use thereof

Cyclohexene derivative and method of producing the same

Growing community of inventors

Takatsuki, Japan

Kazuhiko Sakuma