The Kitasato Institute

Other

Mitsui Sugar Co., Ltd.

Carna Biosciences, Inc.

Kazuhiko Otoguro

Satoshi Omura

Masato Iwatsuki

Aki Ishiyama

Masaaki Sawa

Haruki Yamada

Shigeo Hasegawa

Kanki Komiyama

Kazuro Shiomi

Yoko Takahashi

Jun Kashimura

Toshikazu Kawai

Masami Mizu

Kenji Koge

Yutaka Miyauchi

Yuko Uno

Takuji Nakashima

Hiroaki Kiyohara

Atsuko Matsumoto

Yuko Asamitsu

Rei Hokari

The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof.

Pyrimidine derivative having antimalarial activity

The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains &#x3b1;-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and &#x3b1;-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively.

Peyer's patch activator

The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and asp. K10-0216 strain that produces said compound.

Mangromicin compound and production method therefor

Citrus amanatsudaidai peel extract, which was used as a starting materials was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. Hair growers containing the peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

Peptides and hair growers having actions of promoting proliferation of

Growing community of inventors

Tokyo, Japan

Kazuhiko Otoguro