Takeda Chemical Industries, Inc.

Kazuhiko Ohta

Hisayoshi Okazaki

Kiyoshi Nara

Takashi Suzuki

Tsuneo Kanamaru

Takenori Ishimaru

Kazuyoshi Katamoto

Masahiko Tsuda

Fumio Kikumoto

A process for producing a carboxylic acid ester which comprises reacting a hydroxy compound for example a primary or secondary alcohol, lankacidin C or maridomycin with a carboxylic anhydride in the presence of carboxylesterase as a catalyst in an organic solvent.

Process for producing carboxylic acid esters using carboxyesterase and

The compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, methyl or hydroxymethyl, R.sub.2 is hydrogen or methoxy, R.sub.3 is hydroxy or methoxy, and R.sub.4 is hydrogen or a group ##STR2## is novel, and the compound is of use as inhibitors of animal tissue fibrosis, or biochemical reagents.

Physiologically active substance P-23924, its production and use

The interseparating of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a fractional elution thereof with water containing 0 to 20 percent (V/V) of an organic solvent or solvents.

Method for separating cephalosporins

Inosine and/or guanosine can be separated from fermentation broth containing microbial cells and high-molecular-weight substances by heat-treating said broth at 90.degree. to 110.degree. C., followed by subjecting to ultrafiltration. The present process is advantageously carried out in the industrial use of ultrafiltration.

Ultrafiltration of fermentation broth containing nucleosides to separate

An antifibrotic substance P-1894B is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing P-1894B in a culture medium to have Antifibrotic substance P-1894B elaborated and accumulated in the cultured broth and recovering the substance. P-1894B is effective for the prophylaxis or treatment of the fibrosis due to excessive collagen accumulation in mammal.

Growing community of inventors

Ikeda, Japan

Kazuhiko Ohta