Nissan Chemical Industries Limited

Chugai Seiyaku Kabushiki Kaisha

Kazuhiko Ohrai

Toru Yamashita

Kazufumi Yanagihara

Yukihiro Shigeta

Keizo Tanikawa

Toru Tsukagoshi

Hiroo Matsumoto

Kiyotomo Seto

Yoshimasa Kamikawaji

Yukinori Masuda

Ryozo Sakoda

Yoshio Ohara

Masayuki Sato

Osamu Uesugi

Takumi Okada

Tomoyuki Matsuda

Yukohiro Shigeta

Yoshiaki Watanabe

Masakatsu Shibasaki

Shojiro Kadono

Haruhiko Sato

Takuya Shiraishi

Masahiro Sakaitani

Yoshiyuki Suzuki

Mikiko Sodeoka

Takanori Shimizu

Keishi Hayashi

Masateru Ohta

Nobuya Ishii

Masami Hasegawa

Masataka Minami

Koji Toyama

Michiaki Adachi

Keisuke Ohdoi

Masakazu Sugiyama

Kyoko Nakayama

This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein Rand Rare independently of each other hydrogen atom, Calkyl group or Caryl group, Ris hydrogen atom or Calkylcarbonyloxy group, or together with Rforms a bond, Ris hydrogen atom, or together with Rforms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, amino group, Calkylamino group, di-Calkylamino group, Carylamino group, Cheteroarylamino group, Caryl group, Cheteroaryl group or Cheterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

Tricyclic benzopyrane compound

The present invention provides novel &#x3b1;-amino acid derivatives of formula (1): (wherein, R, R, R, R, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have &#x3b2;ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

&#x3b1;-amino acid derivatives and medicaments containing the same as an active ingredient

This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein Rand Rare independently of each other hydrogen atom, Calkyl group or Caryl group, Ris hydrogen atom or Calkylcarbonyloxy group, or together with Rforms a bond, Ris hydrogen atom, or together with Rforms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, amino group, Calkylamino group, di-Calkylamino group, Carylamino group, Cheteroarylamino group, Caryl group, Cheteroaryl group or Cheterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent. 

Tricyclic benzopyran compound as anti-arrhythmic agents

This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein Rand Rrepresent independently of each other hydrogen atom or Calkyl group, Rrepresents hydroxyl group or Calkylcarbonyloxy group, Rrepresents hydrogen atom or Calkyl group, Rrepresents Calkyl group substituted with Caryl group or heteroaryl group, Rrepresents Calkyl group, Calkoxy group, halogen atom, nitro group, C(O)NH, C(O)NHRor C(O)NRR, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent 

Substituted benzopyran derivatives against arrhythmia

This invention relates to benzopyran derivatives of the formula (I) wherein, R and R represent each independently a C alkyl group, etc, R represents a hydroxyl group, etc, R represents a hydrogen atom, etc, R represents a hydrogen atom, R represents a hydrogen atom, etc, X is absent, or represents C&boxH;O, etc, R represents a hydrogen atom, a C alkyl group, etc, R represents a hydrogen atom or a nitro group, when R represents a nitro group, Y represents a C alkylene group, &mdash;(CH ) &mdash;CR R &mdash;(CH ) &mdash; or &mdash;(CH ) &mdash;O&mdash;(CH ) &mdash;, R represents a hydrogen atom, an amino group, a C alkoxy group, a C alkylthio group, a C alkylamino group, a C alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

4-aminobenzopyran derivatives

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; R represents a hydrogen atom or a C alkyl group; X is absent or represents C&boxH;O or SO ; R represents a hydrogen atom, a C alkyl group or a C cycloalkyl group; R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

4-oxybenzopyran derivative

Benzopyran derivative

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or a C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; n represents an integer of 0-4; X represents &mdash;C(&boxH;O)NR &mdash;, &mdash;NR &mdash;, &mdash;NHC(&boxH;O)NH&mdash; or &mdash;S(O) NH&mdash;; R5 represents a hydrogen atom or (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l); R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to an antiarrhythmic agent having the prolongation effect of the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

Indane derivatives

The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R.sup.1 represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-6 alkoxymethyl group, etc., R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, etc., R.sup.5 represents a hydroxyl group or a C.sub.1-6 alkylcarbonyloxyl group or forms a bond together with R.sup.5, R.sup.6 represents a hydrogen atom or forms a bond together with R.sup.5, R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-6 cycloalkyl group, a phenyl group, etc. n is 0 or an integer of 1, 2, 3 or 4, W represents a phenyl group, etc., X represents C.dbd.O, CH.sub.2, SO.sub.2, etc., Y represents NR.sup.17 (in which R.sup.17 represents a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group, etc.), etc., Z does not exist or represents CH.sub.2 or NR.sup.18 (R.sup.18 represents a hydrogen atom, a C.sub.1-4 alkyl group, or a phenyl group, etc.)] or their salts.

Chroman derivatives

Medicines for cardiac insufficiency

Optically active bidentate phosphine ligand palladium complex

A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.

Pyranobenzoxadiazole derivatives

A compounds of the formula (I): ##STR1## wherein A represents OH or OC(O)CH.sub.3-n X.sub.n, B represents hydrogen atom, or A and B together represent a bond; R.sup.1 represents hydrogen atom, R.sup.2 represents hydrogen atom, C(Z)CH.sub.3-n X.sub.n or C(Z)NHCH.sub.3-n X.sub.n or R.sup.1 and R.sup.2 together represents (CH.sub.2).sub.m, (CH.sub.2).sub.m-1 C(Z), N(R.sup.3)(CH.sub.2).sub.2 C(Z), (CH.sub.2).sub.m-2 NHC(Z) or (CH.sub.2).sub.m-2 OC(Z) in which X represents fluorine atom, chlorine atom, bromine atom, a methyl group or a methoxy group and n represents 0 or an integer of 1 to 3, Z represents oxygem atom or sulfur atom, m represents an integer of 4 or 5 and R.sup.3 represents hydrogen atom or a methyl group, and pharmacological acceptable salts of the compounds which can form salts, processes therefor and pharmaceutical use of the compounds.

Growing community of inventors

Funabashi, Japan

Kazuhiko Ohrai