Takasago International Corporation

Other

Takeda Pharmaceutical Company Limited

Osaka University

Nkk Corporation

Japan Science and Technology Corporation

Asahi Kasei Pharma Corporation

Kazuhiko Matsumura

Takao Saito

Hidenori Kumobayashi

Noboru Sayo

Tohru Yokozawa

Xiaoyong Zhang

Akio Fujii

Ryoji Noyori

Hideki Nara

Takao Ikariya

Hidemasa Takaya

Kenji Yagi

Takeshi Ohkuma

Toshiyuki Murayama

Wataru Kuriyama

Shohei Hashiguchi

Kazushi Mashima

Jun Takehara

Tsukasa Sotoguchi

Noriyoshi Arai

Motonobu Takenaka

Takashi Moroi

Nobuyuki Uematsu

Takashi Miura

Yasushi Kato

Yoshimasa Matsushima

Daiki Kato

Kyoko Tamao

Tetsuo Tomita

Akifumi Yoshida

Kiyoto Hori

Koji Ohno

Satoshi Mano

Nozomu Sakai

Shoko Akiyama

Shinya Akebi

Shusei Soma

Takahiro Hirai

Haruki Nagae

A method for converting an N,N-dialkylamide compound into an ester compound includes using a fourth period transition metal complex as a catalyst. The fourth period transition metal complex is obtained by a reaction of a precursor having a fourth period transition metal with a nitrogen-containing compound or a phosphorus-containing compound.

Method for converting N,N-dialkylamide compound into ester compound using complex of fourth-period transition metal as catalyst

A method for producing, in a few simple steps, a specific optically active aldehyde represented by the general formula (1), in which * is an asymmetric carbon atom, includes asymmetrically isomerizing a specific allyl alcohol represented by the general formula (2) in the presence of a ruthenium complex and a base.

Method of producing optically-active aldehyde

A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein Prepresents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group). 

Process for producing optically active amine

The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for an asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having a ruthenacycle structure, a catalyst for an asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex.

Ruthenium complex and method for preparing optically active alcohol compounds using the same as a catalyst

Disclosed is an industrially advantageous production method of optically active &#x3b2;-amino acid of formula (5), which includes subjecting an enaminoester of formula (4) to an asymmetric hydrogenation: 

Method for producing an optically active tetrahydroquinoline

Disclosed is a producing method of an optically active &#x3b2;-amino acid useful as intermediate for the production of medicines, agricultural. chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. The method includes subjecting an enamine to an asymmetric hydrogenation.

Method for producing an optically active &#x3b2;-amino acid

A ligand represented by the formula (1):RRN-Q-X-Q-NRR&#x2003;&#x2003;(1)wherein R, R, Rand Rare each the same or different and represent a group represented by the formula (2): wherein Qis an optionally substituted alkylene group, an optionally substituted cycloalkylene group, an optionally substituted arylene group, or an optionally substituted divalent heterocyclic group, Ris an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group and Ris a substituent which may coordinate or bind to a metal atom, or Rand R, taken together, may form a ring, Qand Qare each the same or different and represent an optionally substituted alkylene group or a single bond, and X is a divalent spacer.

Ligands and complex compounds containing the same

The present invention relates to a process for producing amino acid derivatives such as optically active &#x3b2;-amino acid in short steps with good yield and high optical purity, which comprises reacting a keto acid of the formula (1): wherein Ris hydrogen, an optionally substituted hydrocarbon, etc.; Ris a spacer; and Ris an optionally substituted alkoxy, etc., or a salt thereof, with ammonia or an amine or a salt thereof in the presence of a chiral catalyst and in the presence or absence of an acid and/or a fluorine-containing alcohol, to give an amino acid derivative of the formula (2): wherein Q is a group formed by removing one hydrogen atom from ammonia or an amine; X' is an acid and/or a fluorine-containing alcohol; and b is 0 or 1.

Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives

The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises:      

To provide a producing method of an optically active &#x3b2;-amino acid useful as intermediate for the production of medicines, agricultural chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. A producing method of an optically active &#x3b2;-amino acids which comprises subjecting an enamine to an asymmetric hydrogenation.

A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.

Method for producing optically active compounds

A novel process for producing an optically active amide excellent in chemical selectivity and enantioselectivity by asymmetric hydrogenation of an &#x3b1;,&#x3b2;-unsaturated amide and also allowing the reaction to proceed efficiently even when a trace amount of a catalyst is used relative to the substrate as compared with the amount in a conventional process. An optically active amide is produced by asymmetric hydrogenation of an &#x3b1;,&#x3b2;-unsaturated amide derivative in the presence of a transition metal complex containing a specific phosphine-phosphorane compound.

Process for producing optically active amide from &#x3b1; &#x3b2;- unsaturated amide derivative in the presence of transition metal complex containing phosphine-phosphorane compound and transition metal

Asymmetric phosphine ligand

A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a &bgr;-keto acid compound through a simple operation. An optically active alcohol represented by general formula (III) as defined is obtained by asymmetrically hydrogenating a &bgr;-keto ester compound represented by general formula (I) as defined in the presence of at least one ruthenium complex having as a ligand an optically active tertiary diphosphine compound represented by general formula (II) as defined.

Process for producing optically active alcohol

Growing community of inventors

Hiratsuka, Japan

Kazuhiko Matsumura