Japan Tobacco Inc.

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Denka Company Limited

National Institute of Infectious Diseases

Tokyo Institute of Technology

The Kitasato Institute

National Center for Geriatrics and Gerontology

Keio University

Japan as Represented by Director General of Agency of National Institute of Infectious Deseases

Kazuhiko Katayama

Manabu Yamada

Takashi Hasegawa

Manabu Takeuchi

Takuma Nakano

Atsuro Yamada

Hiroshi Sasaki

Hirofumi Matsumoto

Akihiko Suzuki

Tomoichi Watanabe

Kimitaka Uchii

Motohiro Miki

Takeshi Shinkawa

Morio Yajima

Reiko Todaka

Takeshi Akiyama

Akira Fujimoto

Kiyoshi Watanabe

Nobutaka Tani

Hiroshi Otsuka

Takehisa Ohashi

Toshiro Sato

Michihiro Inagaki

Masafumi Tarora

Masahiko Nishigaki

Shigeki Hamaguchi

Yoshimasa Takahashi

Yoshinori Fujisawa

Yoshiaki Ishikawa

Yasuhiro Shinozaki

Takafumi Ueno

Akihiro Koide

Hirokazu Nakanishi

Sakari Sekine

Masami Ohnishi

Yoshikazu Kogame

Minoru Nishizawa

Akira Ohtani

Yosuke Ichikawa

Kei Haga

Taishi Onodera

Megumi Mano

Kengo Yoshikawa

Akira Nakanishi

Shigetaka Mimori

Keisuke Haruki

Kimitaka Higuchi

Ueno Takafumi

Yoshikawa Kengo

Mano Megumi

A non-combustion type flavor inhaler comprising: an atomizer atomizing an aerosol source without burning; and a controller controlling a power output to the atomizer, wherein the controller is configured to start supply of a power output to the atomizer before start of a user's puffing action, and is configured to stop supply of a power output to the atomizer during a user's puffing action.

Non-combustion type flavor inhaler and aerosol delivery method

The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L-X&#x2014;Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; Lrepresents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Composite polypeptide monomer, aggregate of said composite polypeptide monomer having cell penetration function, and norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration and having said aggregate as effective component thereof

An object of the present invention is to solve problems in terms of stagnation of research on norovirus by providing a cultured transgenic cell or a transgenic animal in which murine norovirus (MNV) can be grown across the barrier of host specificity in mammalian cells, and providing a screening method that uses the cultured transgenic cell or the transgenic animal. The present inventors have found that MNV infection is determined in a cultured transgenic mammalian cell or a mammal possessing the cultured transgenic mammalian cell as its own cell, the cultured transgenic mammalian cell containing one or more species selected from the entirety or a portion of the murine CD300F gene and/or a CD300 family gene having an extracellular domain nucleotide sequence similar to that of the murine CD300F gene. The present inventors have solved the aforementioned problems by providing, for example, a norovirus-related drug screening method on the basis of this finding.

Cultured transgenic cell allowing growth of norovirus, and use thereof

A smokeless flavor inhalator includes a tobacco material as a flavor generator, and a heater for heating the tobacco material to allow flavor components to be released from the tobacco material while preventing smoke from being generated from the tobacco material. The heater has a carbon heat source and a cooling element. The carbon heat source and the cooling element cooperatively keep the heating temperature of the tobacco material at a temperature of 50 to 200&#xb0; C.

Smokeless flavor inhalator

A method of manufacturing a flavor cartridge for a flavor inhalator, the method comprising the steps of filling a predetermined amount of a flavor generating material capable of emitting a flavor component in a frame compressing the flavor generating material in the frame by applying pressure thereto by a pusher and fixing a lid to the frame, wherein the flavor generating material contains a tobacco material obtained by shredding or pulverizing tobacco leaf, and the lid has air permeability.

Non-heating type flavor inhalator and method of manufacturing flavor cartridge

The production process comprises a step (A) in which an alkali-treated tobacco source is heated to make the tobacco source release a flavoring ingredient into a gas phase, a step (B) in which the flavoring ingredient released into the gas phase is brought into contact with a given solvent which is a liquid substance at ordinary temperature, thereby trapping the flavoring ingredient in the given solvent, and a step (C) in which the given solvent is added to a constituent element.

Manufacturing method of composition element of item including flavor component, and composition element of item, including flavor component

A chewable oral tobacco composition () including a tobacco raw material for eluting a tobacco component and a gum base comprises: a first gum portion () including the tobacco raw material and a first gum base; and a second gum portion () including a second gum base. The second gum portion does not include the tobacco raw material or includes the tobacco raw material in an amount less than an amount of the tobacco raw material included in the first gum portion. A weight of the first gum base is 0.3 g or more. Wt. % of the first gum base is 50 wt. % or more when wt. % of the first gum portion is 100 wt. %. Total wt. % of the first gum base and the second gum base is 50 wt. % or less when wt. % of the oral tobacco composition is 100 wt. %.

Oral tobacco composition

A non-heating type flavor inhalator of the invention includes a hollow cylindrical holder () having an ambient air admission opening () at a front end thereof and a mouthpiece end () at a rear end thereof, and a flavor cartridge () extending inside the holder () from the ambient air admission opening () toward the mouthpiece end () along the axis of the holder (). The flavor cartridge () accommodates a flavor generating material () containing granular tobacco, and the flavor generating material () is kept in a predetermined required compressed state.

A non-heating tobacco flavor suction device () comprises a suction holder () with a suction path defined inside and a filler () arranged in the suction path. The filler () is formed of tobacco particles. The suction path and the filler () arranged therein provide a ventilation resistance of between about 40 and about 80 mmAq in cooperation with each other.

Non-heating tobacco flavor suction device

An aerosol aspirator has a casing () with a mouthpiece () and an outside air inlet (), a generation passage () extending from the outside air inlet () to the mouthpiece (), a syringe pump () arranged within the casing () to deliver a solution to a distributing position (A) in the generation passage in a fixed amount each time it is activated, and a tubular heater () disposed downstream of the distributing position (A) and forming a part of the generation passage. When a user sucks at the mouthpiece (), the solution at the distributing position (A) is transferred from the position (A) into the heater (), and within the heater, atomized, and then turns into an aerosol by condensing in sucked air flow, and the aerosol thus formed is sucked by the user with the air flow.

Aerosol aspirator and aerosol sucking method

An aerosol inhalator has an aerosol generation passage extending from an ambient air inlet () to a mouthpiece (), a liquid supply device () for feeding a predetermined amount of a solution to a feed position (A) in the passage (), a ceramic heater () for heating the solution conveyed from the feed position (A) toward the mouthpiece () with a drawn-in flow of air created in the passage () by a user's sucking action, thereby causing the solution to evaporate and turn into an aerosol in the passage (), and a protector provided at least either at a location near the feed position (A) or at a location between the feed position (A) and the liquid supply device (), the protector having at least one of a radiation cover (), a cooling device () and an open-close valve ().

Aerosol inhalator

A carbonaceous heat source composition for a non-combustion-type smoking article contains calcium carbonate in an amount of 30 to 55% by weight.

Carbonaceous heat source composition for non-combustion-type smoking article

A process for preparing 3-halogeno-2-hydroxy-propyltrimethylammonium halide or especially one having the (S)-configuration, which comprises reacting 2,3-dihydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is obtained by reacting (R)-3-halogeno-1,2-propanediol with trimethylamine, with a halogenating reagent. According to the present invention, 3-halogeno-2-hydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is a useful intermediate for the synthesis of carnitine or especially (l)-carnitine, can be obtained economically, efficiently and easily.

Process for preparing 3 halogeno-2-hydroxypropyltrimethylammonium halide

In the suspension polymerization in an aqueous medium of vinyl chloride alone or of a monomer mixture comprising vinyl chloride as a major component and other monomers copolymerizable therewith as a minor component, depositin of polymer scales on the inside surfaces of the polymerization vessel is surprisingly prevented by coating the interior surface of the vessel and auxiliary equipment prior to the polymerization with at least one compound selected from the group consisting of hydroxyhydroquinone and pyrogallol.

Method of polymerizing vinyl chloride

Growing community of inventors

Tokyo, Japan

Kazuhiko Katayama