Other

Shiseido Company, Limited

Seiko Epson Corporation

Kazuhiko Ishihara

Tokyo Medical and Dental University

Tokai University Educational System

Tokai University

Suntech Co., Ltd

Kazuyuki Miyazawa

Yukimitsu Suda

Fumio Takagi

Yasuhiko Iwasaki

Yu Nagase

Akira Ishikubo

Naoya Shimoyamada

Masataka Oku

Hyung Il Kim

Katsuyuki Maeno

A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.

Bioabsorbable blend for temporary scaffolding of the blood vessel wall

The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy. 

Affinity particle and affinity separation method

The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent. The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof. 

Eye lens material and method of manufacturing thereof

The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.  

Method for producing protein adsorption-preventing ocular lens material

An eye lens material preventing protein adsorption is manufactured by reacting in a reaction medium of either water, an organic solvent, or a water/organic solvent mixture an eye lens material having OH groups with a phosphorylcholine group-containing compound of formula (1), thereby forming an acetal bond according to formula (2) which covalently bonds the phosphorylcholine group-containing compound to a surface of the eye lens material. 

Method of manufacturing protein adsorption preventing eye lens material

Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer. 

Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer

It is an object of the present invention to provide a droplet discharging head suited to the discharge of a sample solution, and particularly one that contains a bio-related substance. This object is achieved by a droplet discharging headfor discharging a sample solution, wherein the portion of the inner walls of the droplet discharging headthat comes into contact with the sample solution is covered with a polymer composed of phosphorylcholine group-containing unsaturated compound units, or a copolymer including same. The droplet discharging head is preferably an electrostatic drive or piezoelectric drive type.

Droplet discharging head and microarray manufacturing method

A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, &#x2014;O&#x2014;, &#x2014;COO&#x2014;, &#x2014;OOC&#x2014;, &#x2014;CONH&#x2014;, &#x2014;NH&#x2014;, &#x2014;NHCO&#x2014;, &#x2014;NR&#x2014; and &#x2014;CHO&#x2014; where Ris an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

Compound having phosphorylcholine group, polymer thereof and process for producing the same

A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological material; and discharging the liquid containing the dispense stabilizer using an inkjet system.

Growing community of inventors

Mitaka, Japan

Kazuhiko Ishihara