The University of Tokyo

Other

Nof Corporation

Kyocera Medical Corporation

Mitsui Petrochemical Industries, Ltd.

Medtronic, Inc.

Kyocera Corporation

Tokyo Medical and Dental University

Suntech Co., Ltd

Hitachi, Ltd.

Asahi Kogaku Kogyo Kabushiki Kaisha

Kabushiki Kaisha Kobe Seiko Sho

Japan Science and Technology Corporation

Biocompatibles Limited

Tokai University Educational System

Kazuhiko Ishihara

Nobuo Nakabayashi

Masayuki Kyomoto

Hiroshi Kawaguchi

Kozo Nakamura

Toru Moro

Yoshio Takatori

Tomohiro Konno

Satoshi Yamada

Ken Suzuki

Kenshiro Shuto

Tomozumi Noda

Masaru Matsuda

Noboru Yamawaki

Patrick T Cahalan

Nobuyuki Sakamoto

Eric J Fogt

Yasuhiko Iwasaki

Kazunori Waki

Akio Hayashi

Takashi Yamamoto

Yasumi Koinuma

Takeo Matsumoto

Daijiro Shiino

Yasukazu Saimi

Hyung-Il Kim

Edouard Koulik

Kazuo Matsuyama

Larik Vincent

Nobuharu Nakada

Yoshishige Murata

Takeshi Nizuka

Hirokazu Nishida

Shinji Tanaka

Tomiharu Matsushita

Yuuki Inoue

Nobuyuki Yamamoto

Hiroki Fukui

Yu Nagase

Toru Kinoshita

Makoto Kondo

Koji Kamenosono

Shuji Kusumoto

Hiroaki Takadama

Shinji Miyazaki

Kazuo Imamura

Kyoko Fukazawa

Hyung Il Kim

Yoshihiro Kiritoshi

Masami Hashimoto

Naoya Shimoyamada

A resin molded body, includes: a polyolefin element including a crystalline region and an amorphous region; and a hydrophilic polymer contained in a region from a surface of the polyolefin element to part of the amorphous region located below the surface. Or, a method for producing a resin molded body, includes: preparing a polyolefin element including a crystalline region and an amorphous region; forming a coating of a hydrophilic polymer on a surface of the polyolefin element; and applying heat treatment to the polyolefin element on which the coating of the hydrophilic polymer is formed, wherein by applying the heat treatment, the coating of the hydrophilic polymer is immersed in a region from the surface to part of the amorphous region located below the surface.

Resin molded body and method for producing resin molded body

A resin molded body includes: a polyolefin element formed of polyolefin, including a crystalline region and an amorphous region; and a hydrophilic copolymer contained in at least part of a surface of the polyolefin element, the hydrophilic copolymer including a copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) of 45% or greater on a mole fraction basis and at least one other monomer. In the resin molded body, the MPC polymer is immersed through the surface by applying heat treatment.

[Problem] To provide a surface treatment polymer. [Solution] A compound represented by formula (1), and a surface treatment agent including the compound. 

Surface treatment agent, surface treatment method, surface treatment base material, and surface treatment base material production method

Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.

Copolymer and application therefor

Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

Slipperiness-imparting agent and slipperiness-imparting method

Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.

Polymer and crosslinked body thereof

An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Medical device and method for producing the same

The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substratecapable of forming hydroxyl groups; and a biocompatible material layerlaminated on appropriate sections of the substrate, wherein hydroxyl groups are formed on at least a required section of a surface of the substrateby surface treating to form a surface-treated layer, while the biocompatible material layeris formed from a polymer containing phosphorylcholine groups, and wherein the substrateand the biocompatible material layerare joined via a binder layerformed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Biocompatible and low-abrasion member, and artificial joint using the same and method of producing the same

An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.

Oligopeptide sequence specifically bonding to phenylboronic acid group

A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.

Bioabsorbable blend for temporary scaffolding of the blood vessel wall

The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing materialfor being used under a humid environment comprising: a base bodymade of a polymer material having a methylene group; and a polymer layercovering a bearing surfaceof the substrate, the polymer layercomprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface, wherein a phosphoric index of the sliding surfacewhich is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.

High wear-resistant bearing material and artificial joint replacement using the same

The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Biomaterial, joint prosthesis using the biomaterial and method of producing the same

Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).

Graft polymerization method and product obtained thereby

Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.

Polymer sliding material, artificial joint member, medical appliance, and manufacturing method therefor

Growing community of inventors

Tokyo, Japan

Kazuhiko Ishihara