Sysmex Corporation

Kazuaki Yamashita

Takeshi Suzuki

Susumu Hoshiko

Yasushi Shirahase

Keisuke Nagai

Tadahiro Kajita

Koji Kishi

Yoko Ueda

The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.

Reagent for assaying D-dimer and kit of reagent for assaying D-dimer

The object of the present invention is to provide a method for more accurately assaying the enzyme activities of mCK isozymes and a method for separately assaying the enzyme activities of CK isozymes by separately assaying the enzyme activities of ubiquitous mCK (umCK) and sarcomeric mCK (smCK). The above object is attained by an assay using an antibody that specifically recognizes umCK protein. In addition, other anti-mCK antibodies (e.g., anti-smCK antibody) and/or anti-human CK-M-inhibiting antibody can also be used. The above antibody is a polyclonal antibody or a monoclonal antibody. As a result of these antibodies, a monoclonal antibody (U1-1881) that is capable of specifically recognizing human umCK and is produced by a hybridoma having a deposition number of FERM BP-8342 is provided.

Mitochondrial creatine kinase antibody

Effective stabilizing amount at least of one antioxidant is added to a composition containing an esterase and surfactant(s).

Reagent for assaying lipid

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Kobe, Japan

Kazuaki Yamashita