Otsuka Chemical Co., Ltd.

Other

Japan Science and Technology Agency

Otsuka Pharmaceutical Company, Limited

Takara Shuzo Co., Inc.

Fuso Pharmaceutical Industries, Ltd.

Glytech, Inc.

Kajihara, Yasuhiro

Kazuaki Kakehi

Yasuhiro Kajihara

Kazuhiro Fukae

Mitsuhiro Kinoshita

Yuki Matsuno

Yusuke Kato

Takashi Hayashi

Satoshi Shimizu

Takahiro Tomoyasu

Takao Taki

Hiroyuki Nishikawa

Atsufumi Kawabata

Yasuo Koga

Hiroaki Asai

Yuan C Lee

Fumitaka Goto

Hiromasa Araki

Shuichi Tanaka

Yoko Sakamoto

Kenzo Kawai

Junji Takaba

Minoru Kashimoto

Naohiro Hayashi

Sachiyo Nishimura

Atsushi Azuma

Wakako Hirano

Kazunari Izumi

Masaru Nishida

Ryotaro Kuroda

Susumu Honda

Satoru Nakazato

Kazuhiro c/o Otsuka Chemical Co Ltd Fukae

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SOH group etc.

Low-molecular polysulfated hyaluronic acid derivative and medicine containing same

A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.

Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative

An asparagine-linked &#x3b1;2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked &#x3b1;2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose in N-acetylglucosamine on the nonreducing terminal side of an asparagine-linked oligosaccharide wherein the asparagine has amino group protected with a lipophilic protective group, and a process for producing these compounds.

Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these

In an in-flow chemical reaction system (A) of the present invention, a sample solution () containing glycoprotein is injected into a reaction tube () in which an alkaline solution continuously flows. When a mixed solution of the sample solution and the alkaline solution reach a thermostat bath (), reaction for cleaving a glycoside linkage takes place, thereby separating a carbohydrate chain from glycoprotein. From the solution containing the carbohydrate chain, alkali is removed by using an ion-exchange column (), so that a fraction of a carbohydrate chain () is collected into a sample tube (). In the in-flow chemical reaction system (A), reaction takes place in minutes, so that reaction time is significantly reduced compared to a conventional method. Thus, a glycoside linkage is readily cleaved with high precision in a short time, thereby separating carbohydrate from a glycoside-linkage-having compound.

Method for separating carbohydrate in glycoside-linkage-having compound, carbohydrate separating system, carbohydrate separating reagent kit, standard sample for carbohydrate separation, and evaluation system

The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

Compositions for preventing and treating digestive organs diseases

Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these

A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC group; a 3-branched asparagine-linked oligosaccharide derivative which contains at least one fucose in N-acetylglucosamine on the nonreducing terminal side of the asparagine-linked oligosaccharide of the derivative; asparagine-linked oligosaccharides and oligosaccharides thereof wherein Q is a lipophilic protective group, biotin group or FITC group.

Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these

Disclosed herein is a method of labelling a sugar at its reducing end by using 1-(p-methoxyphenyl)-3-methyl-5-pyrazolone, thereby analyzing said sugar with high sensitivity, and to a kit to be used for sugar labelling by this method.

Method for labelling sugars

Growing community of inventors

Nara, Japan

Kazuaki Kakehi