Ayerst, Mckenna & Harrison, Inc.

American Home Products Corporation

Kazimir Sestanj

Francesco Bellini

Nedumparambil A Abraham

Jay Edward Wrobel

Adi Treasurywala

Michael Sotirios Malamas

Hans U Immer

Eckhardt S Ferdinandi

Surendra N Sehgal

Verner R Nelson

Joseph M Kelly

Steven Fung

Leslie G Humber

Manfred K Gotz

Michael Kraml

Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-[[6

Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-naphthoylglycines as aldose reductase inhibitors

Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating, diabetic complications.

N-naphthoylglycine derivatives

Disclosed herein are N-acyl-N-naphthoylglycines and methods of their preparation. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-acyl-N-naphthoylglycines as aldose reductase inhibitors

Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl][substituted imino]methyl]-N-methylglycines and methods for their preparation. The N-methylglycines are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-(6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)-substituted

N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-[substituted

Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylg

Disclosed herein are N-acyl-N-napthoylglycines and methods of their preparation. The N-acyl-N-napthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-acyl-N-napthoylglycines as aldose reductase inhibitors

Disclosed herein are naphthalenylsulfonylimidazolidinediones and their thioxo analogs and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful

Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylgl ycine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment of prevention of diabetic complications.

N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxome

Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.

Disclosed herein are tolrestat and oxotolrestat amides and methods of preparation. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl and

Disclosed herein are tolrestat amides and methods of preparation. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N

Disclosed herein are new aldose reductase inhibitors of the formula ##STR1## wherein n is an integer from 1 to 5 and X is a chalcogen, and methods of preparation. The derivatives are useful for treating or preventing diabetic complications.

Growing community of inventors

St. Laurent, Canada

Kazimir Sestanj