Memorial Sloan Kettering Cancer Center

General Electric Company

Kayvan Rahimi Keshari

Albert Chen

Arnaud Comment

Roozbeh Eskandari

Andrew Cho

Valentina Di Gialleonardo

The present technology providesC- andN-labeled probes for imaging one or more mammalian cells using magnetic resonance. Thus,C- andN-labeled arginine (compound of formula I), xanthine (compounds of formula II and formula III), urea (compounds of formula IV), and glutamine (compounds of formula V), stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. Further methods of making the labelled probes and methods of using the probes to detect arginase, xanthine oxidase, and glutaminase metabolites and activity are provided. 

Hyperpolarized and deuterium exchanged hyperpolarizedC andN-labeled xanthine, arginine, glutamine, and urea probes

A system for hyperpolarizing a substance is provided. The system includes a cryostat, a polarizer, and a shuttle. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized. The shuttle is operative to transport the substance while maintaining hyperpolarization of the substance.

System and method for hyperpolarizing a substance and quenching radicals therein

Growing community of inventors

New York, NY, United States of America

Kayvan Rahimi Keshari