Daiichi Sankyo Company, Limited

Daiichi Pharmaceutical Co., Ltd.

Kayoko Motoki

Hideki Kubota

Satoru Miyauchi

Masanori Saito

Masayuki Ito

Takanori Yasukouchi

Hitoshi Iimori

The present invention relates to a novel compound having an effect of inhibiting production/secretion of &#x3b2;-amyloid protein. The present invention provides a compound represented by the general formula (1): 

Pyridylmethylsulfone derivative

Provided is a compound capable of inhibiting production or secretion of &#x3b2; amyloid protein. A compound represented by the following formula (1): (wherein, Rrepresents a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a hydrogen atom or a Calkyl group, and X represents &#x2014;S&#x2014;, &#x2014;SO&#x2014; or &#x2014;SO&#x2014;); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

Heterocyclic methyl sulfone derivative

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Edogawa-ku, Japan

Kayoko Motoki