University of Washington

Kayode K Ojo

Wesley C Van Voorhis

Dustin James Maly

Eric T Larson

Ethan Merritt

Wilhelmus G J Hol

Erkang Fan

Zhongsheng Zhang

Wenlin Huang

Stephen R Plymate

Rama Subba Rao Vidadala

Wilhelmus Gj Hol

Wilhelmus GJ Hol

Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite() and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites() and() are described. In particular, the present disclosure is directed to compositions and methods for inhibiting eithercalcium dependent protein kinases (TgCDPKs) orandcalcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, 

Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases

The present disclosure is directed to compositions and methods for inhibiting either() calcium dependent protein kinases (TgCDPKs) or() and() calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R, and Rare defined herein.

Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases

Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite() and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites() and() are described. In particular, the present disclosure is directed to compositions and methods for inhibiting eithercalcium dependent protein kinases (TgCDPKs) orandcalcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R, and Rare defined herein.

The present disclosure is generally directed to bumped kinase inhibitor (BKI) compositions and methods for treating cancer.

Bumped kinase inhibitor compositions and methods for treating cancer

The present disclosure is directed to compositions and methods for inhibiting either() calcium dependent protein kinases (TgCDPKs) or() and() calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-&#x3b1;]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R, and Rare defined herein.

The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.

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Seattle, WA, United States of America

Kayode K Ojo