Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Kaya Ohashi

Hitoshi Harada

Takashi Inoue

Seiichi Kobayashi

Osamu Asano

Manabu Murakami

Nobuyuki Yasuda

Junsaku Nagaoka

Tatsuo Horizoe

Seiji Yoshikawa

Shigeto Negi

Naoyuki Shimomura

Richard S Clark

Kenji Hayashi

Nobuhisa Watanabe

Yorihisa Hoshino

Tsutomu Kawata

Masanobu Shinoda

Fumiyoshi Matsuura

Toshihiko Naito

Toshikazu Shimizu

Kazuto Yamazaki

Isao Tanaka

Eita Emori

Shunji Kasai

Hideki Yoshitomi

Sadakazu Miyashita

Taro Hihara

Hiroe Minami

Naoki Ozeki

Toyokazu Haga

Hiroshi Akamatsu

Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein Rrepresents hydrogen, hydroxyl, halogen, carboxyl, or Calkyl, L represents single bond or C-alkylene, C-alkenylene, or C-alkynylene, M represents single bond or C-alkylene, C-alkenylene, or C-alkynylene, T represents single bond, or C-alkylene, C-alkenylene, or C-alkynylene, W represents carboxyl, represents single bond, X represents single bond, oxygen, &#x2014;NRCQO&#x2014;, &#x2014;OCQNR&#x2014;, &#x2014;CQNRO&#x2014;, ONRCQ&#x2014;, &#x2014;QSO&#x2014;, or &#x2014;SOQ&#x2014;, Y represents 5- to 14-membered aromatic group, and ring Z represents 5- to 14-membered aromatic group.

Carboxylic acid derivative and salt thereof

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is &#x2014;CHCH&#x2014;, or &#x2014;CH&#x2550;CH&#x2014; or &#x2014;C&#x2261;C&#x2014;; Ris:(in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.; and Rand Rare the same as or different from each other and each represents hydrogen atom, a lower alkyl group, a cycloalkyl group, etc.) and the like; Ris an amino group, etc. which maybe substituted with a lower alkyl group, etc.; Ris a cycloalkyl group, an optionally substituted aryl group, etc.; and Ris a lower alkyl group etc.

Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I);(wherein Rrepresents e.g. an amino group which may be substituted with an alkyl group; Rrepresents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; Rrepresents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.

Condensed imidazole compounds and a therapeutic agent for diabetes mellitus

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Toyko, Japan

Kaya Ohashi