Aurigene Discovery Technologies Limited

Aurigene Oncology Limited

Kavitha Nellore

Subramanya Hosahalli

Susanta Samajdar

Venkateshwar Rao Gummadi

Girish Chandrappa Daginakatte

Wesley R Balasubramanian

Wesley Roy Balasubramanian

The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R, Rand Rwhich have the meanings given in the specification, and pharmaceutically acceptable salts thereof.

Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors

The present invention provides methods of treating hematological disorders, such as acute myeloid leukemia, using substituted heterocyclic compounds and pharmaceutically acceptable salts thereof. The compounds inhibit IRAK4 and FLT-3 kinases.

Compounds and compositions for treating hematological disorders

The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R, Rand Rwhich have the meanings given in the specification, and pharmaceutically acceptable salts thereof. 

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Bengaluru, India

Kavitha Nellore