Streck, Inc.

Kausik Das

Wayne L Ryan

M Rohan Fernando

Gary D Krzyzanowski

Joel Lechner

Rohan M Fernando

Stephanie Wigginton

The invention is composition comprising red blood cells in an aqueous suspension medium and one or more cis di-ahls; wherein more than 6 percent by weight of the hemoglobin in the red blood cells is S-Alc glycated hemoglobin. In another embodiment, the invention is a method comprising contacting red blood cells in a suspension medium having a concentration of S-Alc glycated hemoglobin of greater than 6 percent by weight of the hemoglobin in the red blood cells with a sufficient amount of one or more cis di-ahls such that the concentration of S-Alc glycated hemoglobin in resulting composition as measured by high pressure liquid chromatography, immunoassay and boronate affinity methods is consistent.

Cis di-ahl modified controls for glycated hemoglobin S-A1c derived from healthy blood cells

By way of summary, the present invention meets some or all of the above needs by providing in a first aspect a method comprising contacting red blood cells in a suspension medium containing mannose under conditions such that the concentration of S-Alc glycated hemoglobin is increased to greater than about 6 percent by weight of the hemoglobin in the red blood cells. Preferably the suspension medium is an aqueous suspension medium. In preferred embodiments, the method is performed at about ambient temperature, 18&#xb0; C. to about 23&#xb0; C.

Method of preparing controls for glycated hemoglobin S-A1c derived from healthy blood cells

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Lincoln, NE, United States of America

Kausik Das