Seven Bridges Genomics, Inc.

Kaushik Ghose

Deniz Kural

Wan-Ping Lee

Deniz Kurai

Systems and methods for analyzing genomic information can include obtaining a sequence read including genetic information; identifying, within a graph representing a reference genome, a plurality of candidate mapping positions that relate to the genetic information, the graph comprising nodes representing genetic sequences and edges connecting pairs of nodes; determining, by means of a computer system, whether an alignment with the graph surrounding each of the plurality of candidate mapping positions is advanced or basic; and performing for each candidate mapping position, by means of the computer system, a local alignment based on whether the local alignment is advanced or basic. The advanced local alignment can include a first-local-alignment algorithm, and the basic local alignment includes a second-local-alignment algorithm. Based on the local alignments, the mapped position of the sequence read can be identified within the genome.

Systems and methods for adaptive local alignment for graph genomes

Systems and methods for protecting information stored in private references that are available to be queried&#x2014;e.g., graph-based sequence references that users query through an interface, providing short reads to obtain the results of an alignment against the reference sequence&#x2014;analyze the query and/or alignment results to determine whether the query represents an attack. The analysis may be performed before returning results to a user, and in some cases before performing the alignment.

Data security in bioinformatic sequence analysis

Embodiments of the invention protect information stored in graph-based sequence references by 'watermarking' the graph with uniquely identifiable information. The watermark identifies the graph or version thereof in a detectable but nonintrusive manner. In one embodiment, insertions and/or deletions are introduced into regions of the graph.

Growing community of inventors

Malden, MA, United States of America

Kaushik Ghose