Sun Pharma Advanced Research Company Limited

Kaushik Dhanjibhai Prajapati

Trinadha Rao Chitturi

Bhavesh Mohanbhai Panchal

Jayraj Dilipbhai Aradhye

Biswajit Samanta

Rajan Kumar Pal

Sandeep Pankajkumar Pathak

A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

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Vadodara, India

Kaushik Dhanjibhai Prajapati