Sandoz Pharm. Corp.

Sandoz Gmbh

Kau-Ming Chen

Prasad Koteswara Kapa

Goetz E Hardtmann

Sompong Wattanasin

Jerome Linder

George T Lee

A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium borohydride and an alkoxydialkylborane compound; treating the keto-hydroxy compound with said reaction medium under conditions wherein a cyclic boronate ester is formed; and cleaving the cyclic boronate ester to obtain the dihydroxy product. The product compounds, or derivatives thereof, are useful as anti-atherosclerotic agents.

Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted

Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P.sub.1 is independently an hydroxy group-protecting group, and

Processes for the synthesis of diprotected

An improved process for preparing certain nitrogen-containing mono- and bicyclic ACE inhibitors comprising reacting an .alpha.-alkyl amino acid with a disulfide compound to form a thioester intermediate, which intermediate is then amidated with a mono- or bicyclic amino acid. The invention also relates to the novel thioester intermediates prepared by the first step of the process.

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Randolph, NJ, United States of America

Kau-Ming Chen