Toyo Jozo Kabushiki Kaisha

Katumi Nisimura

Yukio Suzuki

Masao Yaso

Eiichi Hayashi

Tetsu Saito

Noriyasu Takayanagi

Kenzi Saeki

A compound of the formula ##STR1## wherein Z is N or NH,  is a single or double bond, R.sub.1 is hydrogen, C.sub.1-20 alkyl or optionally substituted phenyl, A is lower alkylene, R is carboxyl, lower alkoxycarbonyl, ##STR2## or 1-cycloalkyl-tetrazole-5-yl, R.sub.2 is lower alkyl, hydroxy-lower alkyl or optionally substituted phenyl-lower alkyl, R.sub.3 is lower alkyl or cycloalkyl, or R.sub.2 and R.sub.3 together constitute ##STR3## and R.sub.5 and R.sub.6 are hydrogen or optionally substituted phenyl, or a pharmacologically acceptable salt thereof, has platelet aggregation inhibitory activity and/or cyclic AMP/phosphodiesterase inhibitory activity.

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Shizuoka, Japan

Katumi Nisimura