Sagami Chemical Research Center

Nissan Chemical Industries Limited

Chiba University

Nippon Chemical Industrial Co., Ltd.

Toyo Jozo Company, Ltd.

Katsuyuki Ogura

Genichi Tsuchihashi

Shuichi Mitamura

Ryozo Sakoda

Isao Hashiba

Tadashiro Fujii

Shukichi Nabekawa

Masao Takada

Shuichi Fukushima

Kazuo Nagano

Masashi Kuramoto

Masao Yaso

Suchart Lilitkarntakul

Tetsuo Watanabe

Yumiko Ando

Gehichi Tsuchihashi

1-substituted 2,5-dithienyl pyrrole derivatives and film-forming materials

The present invention relates to pyrrole derivatives, particularly 2-(2-thienyl)-5-(5-tricyanoethenyl-2-thienyl)pyrrole derivatives, which has metallic luster, good stability in air, and a high solubility in an organic solvent, and which is suitable for a film-forming material.

Pyrrole derivatives, film-forming material and method of preparing the derivatives

o-Methoxy benzoic acid is produced by reacting chlorobenzoic acids having at least one chlorine atom at least at the ortho position with lower alcohol in the presence of a copper salt and a lower alkyl as a catalyst under moderate reaction conditions. o-Methoxy benzoic acid is useful as an intermediate for pharmaceutical, agricultural chemicals, and the like.

Method for producing o-alkoxybenzoic acid

An alpha-thio-alpha-aryl-substituted alkanonitrile of the general formula ##STR1## wherein Ar represents an aromatic group, R represents a hydrogen atom or an alkyl group, R.sup.1 represents an alkyl group or an aromatic group, and Y represents an oxygen atom or a carbonyl group. The above compound can be prepared by reacting an alpha-aryl-substituted-alpha-thio-acetonitrile of the general formula ##STR2## wherein Ar, Y and R.sup.1 are as defined above, with an alkylating agent in the presence of a strong base. This compound is useful as an intermediate for producing an alpha-aryl-substituted alkane-carboxylic acid of the general formula ##STR3## wherein Ar, Y and R.sup.1 are as defined above.

Alpha-thio-alpha-aryl-substituted alkanonitrile and process for

The present invention provides .alpha.-methylthio-.alpha.-(p-phthalimidophenyl)-propionic acid and its esters of the formula: ##STR1## wherein R' represents H or C.sub.1 -C.sub.4 alkyl. The subject compounds are useful as intermediates e.g. for Indoprofen.

.alpha.-Methylthio-.alpha.-(p-phthalimidophenyl)-propionic acid

Novel .alpha.-thio-alkanoic acid derivatives and a process for their preparation. These novel compounds can be easily converted to useful medicines.

Novel .alpha.-thio-alkanoic acid derivatives

An o-(N-allyl-2,6-dichloroanilino)phenylacetic acid derivative represented by the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, individually represent a hydrogen atom, a halogen atom or an alkyl group; Y represents a hydroxyl group, an alkoxyl group, a --OM.sup.1 group in which M.sup.1 is an alkali metal atom, a --OM.sub.1/2.sup.2 group in which M.sup.2 is an alkaline earth metal atom, an amino group having the formula --NR.sup.5 R.sup.6 in which R.sup.5 and R.sup.6, which may be the same or different, individually represent a hydrogen atom or an alkyl group, or a hydroxylamino group, and processes for preparing the same.

O-(N-Allyl-2,6-dichloroanilino)phenylacetic acid derivative and a

Aromatic acetic acid derivatives having a sulfur atom at the alpha-position, and a process for their preparation. Useful drugs can be produced from derivatives. erivatives.

Aromatic acetic acid derivatives having sulfur atom at alpha-position

Novel compounds of [N-benzyl-o-(2,6-dichloroanilino)phenyl]acetic acid derivatives having the formula ##STR1## wherein X represents H, Cl, Br or a C.sub.1 -C.sub.4 alkyl group and Y is OH, OR or SR and R represents a C.sub.1 -C.sub.4 alkyl group.

[N-benzyl-o-(2,6-dichloroanilino)phenyl]acetic acid derivatives

Aromatic acetic acid derivatives having a sulfur atom at the alpha-position, and a process for their preparation. Useful drugs can be produced from these derivatives.

Cephalosporins having a sulfur-containing functional group of the formula ##STR1## present at the carbon atom directly bonded to the thienyl or furyl group in the side chain of the 7-position of cephem derivatives. These compounds are useful as anti-bacterial agents against Gram-positive and Gram-negative bacteria.

Cephalosporins having a sulfur containing functional group in the

Commercially advantageous processes for preparing thienylacetic acid, furylacetic acid or alkyl esters of these. Novel thiophene or furan derivatives that can be used as starting materials for preparing the above compounds. Processes for preparing these starting materials are also provided.

Growing community of inventors

Sagamihara, Japan

Katsuyuki Ogura