Tanabe Seiyaku Company, Limited

Katsuyuki Noguchi

Masanori Inamasu

Muneyoshi Ikezaki

Hajime Iwai

Osasi Takaiti

Shigeyoshi Saijo

Masao Wada

Shoichi Harigaya

Junichi Himizu

A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl is prepared by reducing a compound of the formula: ##STR2## wherein R' is benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is the same as defined above, and when R' is benzyloxy, if required, further subjecting the product to catalytic hydrogenation. The compounds (I) and pharmaceutically acceptable acid addition salts thereof are used as anti-diabetic agents.

Novel benzylalcohol derivative and process for preparing the same

Novel 8-azaprostanoic acid derivatives and processes for preparing the same are disclosed. Said 8-azaprostanoic acid derivatives are shown by the formula: ##STR1## wherein R.sup.1 is hydrogen or alkyl of 2 to 6 carbon atoms, R.sup.2 is hydrogen or methyl and R.sup.3 is hydrogen, or R.sup.1 is methyl when R.sup.2 is hydrogen and R.sup.3 is methyl. They exhibit Prostaglandin-like activities and are useful as bronchodilators, stimulating agents for childbirth, abortion or labor, and/or for the treatment of gastro-intestinal disorders.

8-Azaprostanoic acid derivatives

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Kitamoto, Japan

Katsuyuki Noguchi