Japan Tobacco Inc.

Yoshitomi Pharmaceutical Industries, Ltd.

Katsuyoshi Hara

Itsuo Uchida

Koji Matsuda

Junichi Haruta

Minoru Akamatsu

Akihiro Yasuda

Takahiro Yamasaki

Akira Saito

Mutsuyoshi Matsushita

Noboru Furukawa

Kazuhiko Sakuma

Koretake Anami

Kunio Iwata

Yoshinori Hara

Naoki Manta

Kengo Murakami

Hiroaki Hari

The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2,3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, which uses a salt of an organic acid and (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid benzyl.

Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof

Process for producing acetophenone compound

Process for producing oxazole compound

Cyclohexene derivative and method of producing the same

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

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Takatsuki, Japan

Katsuyoshi Hara