Kabushiki Kaisha Yakult Honsha

Katsuyoshi Chiba

Toshiro Sone

Satoshi Yoshikawa

Naoki Izawa

Kouji Miyazaki

Tomoko Hanamizu

Ryoko Iizuka

Takashi Kinoshita

Koji Miyazaki

Ritsuo Aiyama

Yoshio Hiraki

Makoto Ohwaki

Minoru Ichioka

Fukiko Nishisaka

Tomoko Kurasawa

Sachiko Matsumoto

Naohito Saito

Naomi Kondo

Saho Sugimoto

An object of the present invention is to find a novel and useful component in a culture supernatant of a lactic acid bacterium and to provide an effective utilization method of the component. The utilization method is a cytoprotective agent containing, as an active ingredient, a low-molecular-weight fraction in a culture supernatant of a lactic acid bacterium belonging to

Cytoprotective agent

A composition for retarding skin aging which contains an edible herb medicine or medicines round in Taiwan, in particular a plant extract or extracts having melanin formation-unhibiting, elastase-inhibiting, hyaluronidase-inhibiting, active oxygen-eliminating and/or radical-capturing type antioxidant activities, and a medicinally acceptable base and/or additives for external dermal application. The composition is useful in promoting skin whitening effects, maintaining the tension and elasticity of the skin, facilitating skin moistening and providing the skin with anti-inflammatory and/or anti-allergic properties.

Compositions for retarding skin aging

The invention provides an anti-wrinkle agent which has an excellent effect of inhibiting the formation of wrinkles and excellent safeness. The anti-wrinkle agent contains, as an active ingredient, a culture supernatant of a lactic acid bacterium belonging to

Anti-wrinkle agent

External skin preparations containing one or more members selected from among a fermentation product, which is obtained by treating a bean extract with a microorganism, vitamin A and its derivatives. By potentiating skin cells and accelerating the production of hyaluronic acid, these preparations exert effects of preventing and relieving skin roughness, improving keratin, moistening, and preventing and relieving skin tension failure and wrinkles, thereby efficaciously retarding skin aging.

External skin preparations and process for producing the same

Skin preparations for external use and cosmetics which contain a fermented soybean extract prepared by extracting with an organic solvent a fermentation product obtained by treating a soybean extract with one or more microorganisms selected from bifidobacteria. These preparations are excellent in the effects of relieving wrinkles and ameliorating rough skin.

Skin preparations for external use

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Tokyo, Japan

Katsuyoshi Chiba