Eisai Company, Limited

Esai Co., Ltd.

Eisai Inc.

Katsuya Tagami

Shigeki Hibi

Makoto Okita

Shinya Abe

Hiroyuki Yoshimura

Yasushi Okamoto

Mitsuo Nagai

Kouichi Kikuchi

Takayuki Hida

Shigeru Souda

Takashi Yamanaka

Toshihiko Kaneko

Seiichiro Nomoto

Manabu Murakami

Kiyoshi Oketani

Naoki Kobayashi

Seiko Higashi

Isao Yamatsu

Kenji Tai

Seiichi Kobayashi

Ieharu Hishinuma

Junichi Nagakawa

Naoki Tokuhara

Shuhei Miyazawa

Norihiro Ueda

Naoyuki Shimomura

Hisashi Shibata

Masatoshi Fujimoto

Tsuneo Wakabayashi

Hideaki Fujisaki

Makoto Asada

Norimasa Miyamoto

Aichi Ogasawara

Tetsuya Kawahara

Masanobu Shinoda

Hirotoshi Numata

Takeshi Suzuki

Yoshimasa Machida

Takashi Sato

Kouichi Katayama

Takashi Inoue

Hiroshi Shirota

Kenichi Chiba

Hideki Ono

Kaname Miyamoto

Ryoichi Hashida

Masayuki Tanaka

Masaki Goto

Hideto Ohhara

Hideki Sakurai

Yumiko Nagasaka

Hironori Ikuta

Kenji Hayashi

Kazuo Hirota

Yoshio Fukuda

Issei Ohtsuka

Makoto Kaino

Hiromitsu Yokohama

Tsutomu Yoshimura

Yoshihito Eguchi

Yasunori Akita

Koichi Katayama

Hironobu Hiyoshi

Ichirou Yoshida

Makoto Nakagawa

Tohru Horie

Koukichi Harada

Koichi Abe

Hirofumi Kuroda

Akio Kayano

Nobuo Niikawa

Heterocycle-containing carboxylic acid derivative and drug containing the same

Mono- or polyenic carboxylic acid derivatives

Carboxylic acid derivatives having fused rings

Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I):

Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R,is hydrogen, methoxy or difluoromethoxy; R,is methyl or methoxy; R,is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R,is hydrogen or methyl

Process for the preparation of pyridine derivatives

To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:

Fused-ring carboxylic acid derivatives

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

Compounds of the formula and compounds of the formula ##STR1## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.

Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.

Pyridine derivatives having anti-ulcerative activity

Heterocycle-containing carboxylic acid derivative and drug containing

Mono-or polyenic carboxylic acid derivatives

Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are disclosed.

Growing community of inventors

Ibaraki, Japan

Katsuya Tagami