Nippon Shinyaku Company, Ltd.

Other

Mitsubishi Chemical Industries Limited

Wakamoto Pharmaceutical Co., Ltd.

Katsuya Ohata

Hiromu Murai

Hiroshi Enomoto

Katsuhide Saito

Yoshiaki Yoshikuni

Shoichi Chokai

Takayuki Ozaki

Kenji Sempuku

Yoshiaki Aoyagi

Fusao Ueda

Koji Kitaguchi

Yukio Fujita

Kohei Kura

Tamiki Mori

Yasuo Yasutomi

Satoshi Tsutsui

Masahiko Kitano

Sho Inoue

Shinichi Tada

Mitsuhiro Maehara

Mitsuhiro Machara

Tatsuo Nomura

Masahiro Yagi

Touru Oguma

Tatsuhiko Kono

Toshio Kuroda

Tadatoshi Nomura

Yoshihiro Tsuriya

Tooru Abe

Terumasa Hashimoto

Yoshiaki Ogasawara

Shigekatsu Kohno

Takao Shida

Yukiyoshi Yanagihara

Katsahide Saito

Masayoshi Watanabe

Satoshi Takata

Shinji Kageyama

5-(3-n-Butyloxalylaminophenyl) tetrazole having an excellent SRS-A release-inhibiting effect is used as an effective component for an anti-asthmatic agent, and a pharmaceutical preparation obtained by mixing the tetrazole with a specific dispersant such as polysorbate-80 in coexistence with a non-aqueous solvent shows high dissolubility and bioavailability.

Anti-asthmatic composition and process for preparing the same

Hemostatics, vascular stabilizers and anti-shock compositions containing at least one steryl-.beta.-D-glucoside or monopalmitates thereof, of the formula: ##STR1## in which R.sup.1 is .beta.-sitosteryl, campesteryl, stigmasteryl or cholesteryl, and R.sup.2 is hydrogen or palmitoyl. Methods of use are also described.

Steryl-.beta.-D-glucoside pharmaceutical compositions and use

A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.

Morpholinone derivatives and method of use

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Substituted N-(carboxymethyl)-3-aminopropan-2-ol derivatives

2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptacle salts thereof have been found to be effective for meliorating inflammation in warm blooded animals.

2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable salts

2,4-Diamino-6-phenyl-s-triazine derivatives which are substituted in the 3-position of the phenyl ring and optionally further substituted in the 6-position demonstrate anti-ulcer and diuretic properties. A representative embodiment is 2,4-diamino-6-(3-trifluoromethylthiophenyl)-s-triazine.

Benzoguanamine derivatives

2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable salts thereof have been found to be effective for meliorating inflammation in warm blooded animals.

2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable acid

The mono-, bis- and trisnicotinoyl derivatives of melamine and the corresponding mono- and bisnicotinoyl derivatives of benzoguanamine demonstrate anti-ulcer and diuretic activity. A representative embodiment is 2-nicotinamido-4,6-diamino-s-triazine.

Nicotinamido-s-triazines

New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.

Method and composition for reducing blood glucose levels

Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.

Abietanilides, their production and use

Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.

N-(substituted phenyl and benzyl)abietamides

A series of novel benzoguanamine derivatives possessing a high anti-peptic ulcer activity with low toxicity has been prepared by the reaction of the corresponding dihalogenobenzonitriles with dicyandiamide or by the reaction of the corresponding carboxylic acids or functional derivatives thereof with biguanide.

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Kyoto, Japan

Katsuya Ohata