Shionogi Company Limited

Keio University

Katsutoshi Yamada

Tatsuya Takahashi

Yoshito Numata

Shoichi Naito

Junji Onoda

Shoji Yamane

Kazuhiko Maekawa

Tasuku Tsukamoto

Kazuhiro Hasegawa

Hiroshi Itoh

Takashi Ono

Takeshi Kanda

Toshihiro Shinosaki

Shu Wakino

Norito Yoshimura

Yoshinari Gahara

Motoaki Komatsu

Yasuhiko Sato

Provided is a monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.

Method of inhibiting the enzymatic activity of vascular endothelial lipase with a monoclonal antibody

Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase

This invention is related to a therapeutic agent for treating chronic kidney disease comprising a substance which inhibits the enzymatic activity of NNMT or suppresses NNMT gene expression, or a method for screening a therapeutic agent for treating chronic kidney disease which targets the NNMT enzyme or NNMT gene.

Pharmaceutical composition for treating chronic kidney disease

Provided is a monoclonal antibody or a fragment thereof that selectively inhibits enzyme activity of EL and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.

Monoclonal antibody against EL which inhibits enzyme activity of EL

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Toyonaka, Japan

Katsutoshi Yamada