Nisshin Flour Milling Co., Ltd.

Katsutoshi Miura

Masato Horigome

Hiroyasu Koyama

Hiroaki Yamada

Toshiji Sugai

Einosuke Sakurai

Makoto Yanai

Shigeru Hiramoto

Norio Oshida

Noriyoshi Sueda

Nobuhiro Kinoshita

Kazuhiko Yamada

Yoko Tsukada

Fumihisa Nakata

Koichi Katsuyama

Koichi Katasuyama

Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Urea derivatives and their use as ACAT inhibitors

Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.3 alkyl or diphenylmethyl; Y is --NH(CH.sub.2).sub.n --R.sub.2 ; R.sub.2 is OH or --ONO.sub.2 ; m is 2 or 3; and n is 9 to 13 or physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing and hypotensive actions and can be used for the therapy or prevention of diseases in the cardiovascular system.

Pyridinecarboxylic acid amide derivatives and pharmaceutical

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;

Nicotinic acid derivatives and pharmaceutical compositions comprising

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen; C.sub.1 -C.sub.6 alkyl; C.sub.3 -C.sub.6 cycloalkyl or diphenylmethyl;

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Saitama, Japan

Katsutoshi Miura