Nanocarrier Co., Ltd.

The University of Tokyo

Katsutoshi Kobayashi

Kazunori Kataoka

Yasuki Kato

Mitsunori Harada

Hiroyuki Saito

Chieko Tsuchiya

Ryosuke Tanaka

Shoko Nagasaki

A pharmaceutical composition includes a block copolymer having a hydrophilic segment, a hydrophobic segment, and a boronic acid compound bound to a side chain of the hydrophobic segment via a linker moiety that includes a heterocyclic structure. The heterocyclic structure contains a cyclic skeleton that includes a boron atom of the boronic acid compound, one or two atom(s) X bound to the boron atom and selected from an oxygen atom and a nitrogen atom, and one or two carbon atom(s) (respectively) bound to the atom(s) X. The block copolymer further includes at least one organic group bound to the carbon atom(s). The organic group(s) contain(s) an aromatic group or cyclic alkyl group that sterically protects a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atom(s) X.

Pharmaceutical composition containing a block copolymer bound to a boronic acid compound

There is provided a production method in which bis(nitrato)platinum complex, optionally in the concurrent presence of dihalo-platinum complex, and poly(ethylene glycol)-block-poly(glutamic acid) are used at specific ratios and reacted. Coordination compound of an anti-tumor platinum complex with a block copolymer having carboxyl groups on its side chains is efficiently produced.

Method for producing polymerized coordination compounds of platinum complex

Growing community of inventors

Kashiwa, Japan

Katsutoshi Kobayashi