Shionogi Company Limited

Drug Delivery System Institute, Ltd.

Katsutoshi Aono

Kazuhiro Inoue

Satoshi Okuno

Tetsushi Totani

Teruomi Ito

Takayuki Kawaguchi

Toshiro Yano

Akira Kugimiya

Tamio Sugawara

Teruhisa Ichihashi

Osamu Shiratori

Koichiro Hirano

Teruhisa Ichinashi

Yasuko Adachi

Michihiro Komura

Naomi Uchida

Tricyclic compound having acyloxymethoxycarbonyl side chain

Lymph-absorbable aryl substituted imidazole derivatives

A carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) and salt thereof. Further, the invention discloses a carboxymethylmannoglucan derivative and salt thereof produced by subjecting part or the whole of mannose of the tetrasaccharide units to ring opening and subjecting part or the whole of glucose which constitute the main chain but have no mannose as a branch ##STR1## wherein R.sup.1 to R.sup.12 each represent a hydrogen atom or a carboxymethyl group. The compounds are useful as carrier for delaying the disappearance of a drug in the blood and for enhancing the organotropism of the drug for a carcinoma.

Carboxymethylmannoglucans and derivatives thereof

N-acetylcarboxymethylchitosan derivatives and process for preparation

A compound of the formula (I): ##STR1## (wherein R is C.sub.1 -C.sub.6 alkyl, hydroxy, carboxy, C.sub.1 -C.sub.6 alkoxy, halogen or oxo; m is an integer from 2 to 7; X and Y each is chlorine or nit-rato ligand, or taken together form --OCOCH(R.sup.1)O--, OCOCOO--, ##STR2## R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, hydroxymethyl, halogmethyl or phenyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.5 alkyl; and n is an integer from 2 to 5), being useful as antitumor agents is provided.

Ammine-alicyclic amine-platinum complexes and antitumor agents

Novel platinum (IV) complexes having potent antitumor and antibacterial activities and high water solubility with low toxicity and pharmaceutical and/or veterinarily compositions containing one or more compounds together with one or more carriers are provided. They can be prepared by reacting a corresponding platinum (II) complex with hydrogen peroxide or halogen.

Platinum complexes

Novel platinum complexes of glycolic acid type having potent antitumor activity and high water solubility with low nephrotoxicity and a pharmaceutical composition containing one or more said compounds together with one or more carriers, diluents or excipients are provided. They can be administered parenterally to patients suffering from malignant tumors. They are prepared by passing nitrato-platinum complexes of amines through anion exchange resins and subsequent reaction with glycolic acids.

Glycolic acid type platinum complexes

Novel water-soluble glycolic acid platinum complexes which have more potent antitumor activity with lower nephrotoxicity than cisplatin are provided. They can be administered parenterally to mice attacked by malignant tumors. Prepared from dinitrato-platinum complexes of amines on treatment with anion exchange resins and subsequent reaction with glycolic acid.

Glycolic acid platinum complexes

Growing community of inventors

Nara, Japan

Katsutoshi Aono