Takara Shuzo Co., Inc.

Takara Bio Inc.

Other

Nippon Kayaku Kabushiki Kaisha

Nippon Shinyaku Company, Ltd.

Research Institute for Glycotechnology

Takaru Shuzo Co., Ltd.

Katsushige Ikai

Ikunoshin Kato

Nobuto Koyama

Takeshi Sakai

Hiroaki Sagawa

Kazuo Shimanaka

Kaoru Kojima

Tatsuji Enoki

Eiji Nishiyama

Takanari Tominaga

Hitomi Kimura

Eiji Kobayashi

Teruya Nakamura

Hiromu Ohnogi

Yoshikuni Nakanishi

Fu-Gong Yu

Kazutoh Takesako

Junko Yamamoto

Hideyo Yamaguchi

Hua-Kang Wu

Katsuhisa Uchida

Fumiyo Haruna

Yoshihisa Umeda

Sumiko Akiyoshi

Kaoru Katayama

Takashi Kawai

Makoto Moriguchi

Hideo Kitano

Hiroshi Kihara

Hitomi Amarume

Shinji Nakayama

Hiroshi Enomoto

Tetsushi Saino

Jun Tomono

Hideto Chono

Yoji Ezure

Akihiro Kondo

Michio Hagiya

Nobuko Muraki

Takaaki Ohkuma

Kazuyori Ochiai

Hiroshi Kobori

Hiroyuki Kuroda

Suzu Deguchi

Masao Funakoshi

Hironobu Hiraga

Motoko Ueda

Tatsui Enoki

Shinji Okuda

Kumiko Ishizuka

Susumu Sano

Yoko Tatsumi

Food or beverage where fucoidan which is derived from a fucoidan-containing substance is contained therein, added thereto and/or diluted therein. Food or beverage where fucoidan which is derived from a fucoidan-containing substance and where algins are reduced or eliminated, is contained therein. Apoptosis-inducing food or beverage where an effective amount of fucoidan having an apoptosis-inducing ability is contained therein.

Food or beverage containing fucoidan and method of production thereof

Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

Use of algae-derived physiologically active substances for treating a carcinomatous disease

Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

Glucuronofucan sulfate

An enzyme which decomposes a sulfated fucoglucuronomannan and is useful in the field of glycotechnology; a process for producing the enzyme; a fucoidan fraction reduced in the number of the kinds of molecules and useful as a reagent in glycotechnology; a sulfated fucoglucuronomannan oligosaccharide; and processes for producing the fraction and oligosaccharide.

Sulfated fucoglucuronomannan

A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

Sulfated fucan oligosaccharide

Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I):These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.

Drugs, foods or drinks with the use of algae-derived physiologically active substances

Substances capable of inducing apoptosis

A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance.

Substance for inducing apoptosis

Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

Apoptosis inducers

Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

Sulfated fucogalactan

Food or beverage additive containing fucoidan and food and beverage containing fucoidan

Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula &lsqb;I&rsqb;, optically active isomers and salts thereof, wherein R and R are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

Remedies or preventives containing cyclopentenone compounds as the active ingredient

Therapeutic agents

Apoptosis inducer

Growing community of inventors

Shiga, Japan

Katsushige Ikai