Kuraray Co., Ltd.

Katsushi Nagareda

Shigeaki Suzuki

Takashi Onishi

Koichiro Isoue

Junichi Fuji

Jin Tokuyasu

Shigeru Okano

Yoshihiro Tokuda

The method of the invention for continuously producing 2,5-dihydrofuran includes subjecting cis-2-butene-1,4-diol to liquid-phase dehydration-cyclization reaction in the presence of alumina, characterized in that the sum of the concentration of carbonyl compounds present in the reaction system and the concentration of acetal compounds present in the reaction system is controlled to fall within a range of 0.1 to 2 mol/L, provided that the concentration of the acetal compounds is calculated in terms of acetal groups, the concentrations being determined on the basis of the total amount of the reaction mixture. According to the method, 2,5-dihydrofuran, which is useful as a raw material or intermediate for producing pharmaceuticals, agrochemicals, raw materials of polymers, etc., can be continuously produced. The method can prevent inactivation of &#x3b3;-alumina and is advantageous for long-term production on an industrial scale.

Method for continuously producing 2,5-dihydrofuran

An aminoalcohol is synthesized by reacting a cyclic hemiacetal expressed by Formula 1

Method for manufacturing aminoalcohol

A process for producing diamines by reacting a dialdehyde with ammonia and hydrogen in the presence of a hydrogenation catalyst to produce the corresponding diamine, where a solvent comprising an alcohol is used in the reaction and the concentration of water in the reaction mixture is 5 to 15% by weight.

Process for producing diamines

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Ibaraki, Japan

Katsushi Nagareda