Sanraku-ocean Co., Ltd.

Sanraku Incorporated

Katsuro Kubo

Tomoyuki Ishikura

Yasuo Fukagawa

Hamao Umezawa

Tomio Takeuchi

Takeo Yoshioka

Akihiro Yoshimoto

Tsutomu Sawa

Mitsuyasu Okabe

Shizuka Fujii

Novel anthracycline antibiotics characteristic of Ring A of the anthracycline skeleton are produced by microorganisms belonging to the genus Streptomyces and are useful as anti-cancer agents. The antibiotics designated D-788-6 to -10 are shown by general formula: ##STR1## wherein Y represents a group shown by: ##STR2##

Anthracycline antibiotics

Novel phosphoric ester of antibiotic OA-6129 presented by the formula ##STR1## wherein R is a hydrogen atom, hydroxyl or hydroxysulfonyloxy, and its salts and the preparation method thereof.

Phosphoric ester of antibiotic OA-6129

A novel enzyme, amidohydrolase, having the ability to depantothenylate antibiotic OA-6129A represented by the following formula ##STR1## but no substantial ability to deacetylate antibiotic PS-5 represented by the following formula ##STR2##

Amidohydrolase having ability to depantothenylate an antibiotic

Growing community of inventors

Fujisawa, Japan

Katsuro Kubo