Tosoh Corporation

Toyo Soda Manufacturing Co., Ltd.

Nippon Carbon Co., Ltd.

Taisho Pharmaceutical Co., Ltd.

Toson Corporation

Katsuo Komiya

Yoshio Kato

Hiroo Sasaki

Ryuichi Kitayama

Hiroyuki Moriyama

Hiroshi Ichikawa

Akira Yokoyama

Takanobu Kawai

Koji Nakamura

Mitsunobu Sato

Shigenobu Yano

Masazumi Hasegawa

Hironaka Aihara

Satoshi Fujii

Yuji Kubo

Tadao Ohnaka

Yumiko Asami

Hiroshi Wakizaka

Toshikuni Koga

To provide a medium suitable for high speed/high resolution, rich in hydrophilicity and resistant to a high concentration aqueous alkaline solution. A medium comprising crosslinked polymer particles containing from 20 to 95 mol % of repeating units derived from a (meth)acryloyl monomer represented by the formula (1): wherein Ris a hydrogen atom or a Calkyl group, Ris &#x2014;NR-R-Ror &#x2014;O&#x2014;R-R, Ris a hydrogen atom or a Calkyl group, Ris a Calkylene group containing an alicyclic ring or a Clinear alkylene group, and Ris a halogen atom, an alcoholic OH group, an amino group, a glycidyl group or an epoxy group.

Packing material with excellent hydrophilicity and process for producing the same

A packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved. Separation and purification, or collection and recovery, of a biopolymer, is carried out by liquid chromatography by means of a packing material for liquid chromatography comprising a base matrix and a ligand immobilized to the base matrix, wherein the base matrix is a hydrophilic base matrix having alcoholic hydroxy groups on its surface, the ligand is at least one ligand selected from the group consisting of an &#x3b1;-amino acid which is immobilized to the base matrix by an amide bond or an urethane bond via the amino group contained in the &#x3b1;-amino acid.

Packing material for liquid chromatography and process for separation and purification of biopolymer by means of the packing material

A process for production of a partially hydrophilized absorbent is described, which comprises using, as a starting material, porous particles made of an organic compound having properties such that they are shrunk in a solvent containing water as a major component and swollen in a solvent containing an organic solvent as a major component; newly introducing functional groups to react with any one compound selected from the group consisting of compounds containing hydroxyl, amino, carboxyl, halogen or epoxy group in a solvent containing an organic solvent as a major component; and then reacting with a compound containing alcoholic OH group in a solvent containing water as a major component to immobilize the compound containing alcoholic OH group on the outer surfaces of the particles.

Process for production of partially hydrophilized porous adsorbents

A microspherical packing for liquid chromatography, which comprises a porous silicon carbide having numerous through-pores, and a process for producing said microspherical packing.

Packings for liquid chromatography and process for producing the same

An ion exchanger comprising a particle of an insoluble crosslinked polymer having alcoholic hydroxyl groups, as a base material, and a glycidyl-adduct of polyol and/or its oligomer, as a spacer, wherein ion exchange groups are attached to the spacer.

Ion exchange resins containing glycidyl ether spacer groups

A packing material for liquid chromatography is produced by mixing 1.0 part by weight of carbon black, 0.5 to 2.5 parts by weight of one or a mixture of a synthetic resin which can be graphitized by heating and a toluene- or benzene-soluble component of pitches, and an organic solvent to obtain a mixture. The carbon black has a particle diameter of 12 to 40 nm, a specific surface area of 50 to 650 m.sup.2 /g, a DBP oil absorption amount of 50 to 150 ml/100 g. The synthetic resin is one selected from phenol resin, furan resin, furfural resin, divinylbenzene resin and urea resin. The pitches are ones selected from petroleum pitches, coal-tar pitches and liquefied coal oil. The mixture is granulated by spray granulation or emulsion granulation to obtain granules whose ratio L.sub.min /L.sub.max of a minor axis diameter L.sub.min to a major axis diameter L.sub.max is 0.90 to 1.0. The heat treatment of the granules is also made in an inert gas under pressure.

Packing material for liquid chromatography and method of manufacturing

A packing material for reversed phase chromatography, which comprises silica gel with its entire surface substantially coated with repeating units of a polycarbosilane of the formula (I): ##STR1## wherein R.sub.1 is an octyl group, an octadecyl group or a phenyl group, R.sub.2 is a methyl group or a methylene group, and n is a positive integer.

Packing material for reversed phase chromatography and process for its

A method for lowering serum total cholesterol in an animal by administering to the aminal an anion-exchange resin having the monomer units respectively represented by the below-given structural formulas (I), (II), (III) and (IV) in a content of 60-95 molar % of the monomer unit (I), 0-25 molar % of the monomer unit (II), 0--30 molar % of the monomer unit (III) and 1-6 molar % of themonomer unit (IV). ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different respectively are hydrogen atom, a lower alkyl group or benzyl group, R.sup.4 is hydrogen atom, a lower alkyl group or hydroxy-methyl group and X is a halogen atom. The above-mentioned agents specifically bind with bile acid in the intestinal tract even in the presence of other acids.

Cholesterol-lowering agents

A method for chemically modifying an anionic metal complex, by obtaining from an anionic metal complex insoluble in a non-aqueous solvent and a clathrate compound a clathrate complex thereof with a counter cation of said metal complex, which is soluble in a non-aqueous solvent, and then reacting functional groups of the metal complex, which are not concerned with the coordination of said metal complex, with an organic reagent in the presence of a reaction assistant. The central metal from the chemically modified metal complex may then be removed.

Method for chemically modifying a metal complex

A method for chemically modifying an anionic metal complex, by obtaining from an anionic metal complex, insoluble in a non-aqueous solvent and a clathrate compound a clathrate complex thereof with a counter cation of said metal complex, which is soluble in a non-aqueous solvent, and then reacting functional groups of the metal complex, which are not concerned with the coordination of said metal complex, with an organic reagent in the presence of a reaction assistant.

Method for chemically modifying an anionic metal complex

A packing material for chromatography comprising a carrier having silanol groups on its surface, wherein Si in the silanol groups forms a Si--O--Si bond together with Si in a silyl group of the following formula I and Si in a silyl group of the following formula II, and the molar ratio of the silyl group of the formula II is from 0 to 2/3 based on the total amount of silyl groups: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydroxyl group, a methyl group, an ethyl group, an alkoxy group having from 1 to 3 carbon atoms, a phenoxy group, an acetoxy group, a trimethylsiloxy group, a triethylsiloxy group or an oxygen atom bonded to Si in a silanol group on the surface of the carrier, R.sub.3 is a 3-carbonyloxypropyl group, a 1-phenyleneethyl group or a 2-phenyleneethyl group, R.sub.4 is a hydrogen atom or a methyl group, and each of m and n is an integer of at least 1; and ##STR2## wherein each of R.sup.1 and R.sup.2 is a hydroxyl group, a methyl group, an ethyl group, an alkoxy group having from 1 to 3 carbon atoms, a phenoxy group, an acetoxy group, a trimethylsiloxy group, a triethylsiloxy group or an oxygen atom bonded to Si in a silanol group on the surface of the carrier, R.sub.5 is a methyl group, an ethyl group or a 3-glyceryloxypropyl group.

Packing material and process for its production

A packing material for liquid chromatography, which comprises an optically active compound having the formula: ##STR1## wherein Ar is a phenyl group, an .alpha.-naphthyl group or a .beta.-naphthyl group, R.sub.1 is an alkyl group having from 1 to 4 carbon atoms, a phenyl group or a 3,5-dinitrophenyl group, R.sub.2 is an alkyl group having from 1 to 4 carbon atoms, *indicates an asymmetric carbon atom and n is an integer of 2 or 3, as a stationary phase.

Packing material for liquid chromatography

A hydrophilic separating carrier is a porous spherical gel having primary hydroxyl groups and is produced by an aqueous suspension homopolymerization of pentaerythritol dimethacrylate or an aqueous suspension copolymerization of pentaerythritol dimethacrylate and a methacrylate monomer having hydrophilic group and/or hydrophilic convertible group.

Growing community of inventors

Hikari, Japan

Katsuo Komiya