Sankyo Company, Limited

Ube Industries, Inc.

Katsuo Kamoshita

Katsutoshi Fujii

Shinsaku Kobayashi

Mikio Kojima

Shigeki Nagai

Takeo Honda

Takashi Kobayashi

Kiroku Oda

Hiroshi Fujita

Yasunobu Sato

Takagi

4-Anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group;

4-Anilinoquinazoline compounds and pharmaceutical compositions thereof

A method of using 4-anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen, atom, a trifluoromethyl group or a nitro group;

Method of using 4-anilinoquinazoline derivatives as analgesic and

3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers. The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.

Pyrido[1,2-a]pyrimidinone derivatives

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Katsuo Kamoshita