Riken Corporation

Glytech, Inc.

Osaka University

Mitsubishi Heavy Industries Limited

Katsunori Tanaka

Shigemi Mandai

Wataru Akizuki

Keijirou Saitoh

Masaki Ono

Masumi Nomura

Yasuyoshi Watanabe

Masaharu Nishimura

Kiyoshi Suenaga

Takahiro Yamamoto

Kazufumi Ikeda

Atsushi Maekawa

Masaaki Matsuura

Yutaka Kawata

Keizo Ohnishi

Masahito Kataoka

Taiji Shimoda

Yujiro Shimizu

Yasuhiko Ikegami

Koichi Fukase

Isao Sagawa

Akihiro Ogura

Teruaki Akamatsu

Tsuyoshi Tahara

Shigeo Okamoto

Koki Hasegawa

Tsutomu Sakagami

Ambara Rachmat Pradipta

Kenward Vong

Soichiro Tomimoto

[Problem] To provide a novel artificial protein catalyst that enables the protection of a catalyst from substances in vivo and has potential usefulness in therapeutic in vivo synthetic chemistry. [Solution] Provided is a complex of a protein and a catalyst selected from a metal catalyst or organic catalyst. In the complex according to the present invention, the protein is a protein having a hydrophobic pocket in the three-dimensional structure thereof, and the catalyst is housed in the hydrophobic pocket so that the catalyst is not or substantially not exposed to a hydrophilic environment.

Artificial protein catalyst

Provided are, for example, (i) a drug that reacts with acrolein and (ii) a use thereof. A drug that reacts with acrolein in accordance with an embodiment of the present invention contains a compound having a chemical structure represented by Formula (1):

Drug that reacts with acrolein, use thereof and novel compound

An object of the present invention is to provide an albumin-sugar chain complex bound with a number of sugar chains sufficient for obtaining a sugar chain clustering effect while also being able to exist comparatively stably in the body. The present invention provides an albumin-sugar chain complex having five or more molecules of an asparagine-linked sugar chain bound per molecule of albumin; a carrier for selectively delivering a functional molecule to a target tissue in the body that contains the aforementioned albumin-sugar chain complex; and a bioimaging probe having the aforementioned albumin-sugar chain complex as an active ingredient thereof that is administered into the body of an animal.

Albumin-sugar chain complex

A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-&#x3b2;-carbonyl compound represented by Formula (I), a hexatriene-&#x3b2;-carbonyl compound represented by Formula (II), a hexatriene-&#x3b2;-carbonyl compound represented by Formula (III) and a hexatriene-&#x3b2;-carbonyl compound represented by Formula (IV). (wherein R, R, R, R, R, X, Xand Z are as defined in the specification)

Hexatriene-&#x3b2;-carbonyl compound

Growing community of inventors

Wako, Japan

Katsunori Tanaka