Ube Industries, Inc.

Daiichi Sankyo Company, Limited

Sankyo Company, Limited

Katsunori Takata

Takahiro Motoyama

Masahiko Hagihara

Noriaki Iwase

Kenji Yoneda

Atsuyuki Kasai

Yasuaki Fukuhara

Masato Uemura

Tatsunori Sado

Osamu Kikuchi

Masayuki Tanaka

Hiroyuki Koike

Teruhiko Inoue

Tsuyoshi Nakamura

Fumitoshi Asai

Hidenori Namiki

Atsuhiro Sugidachi

Hidetoshi Sunamoto

Yoshiaki Kuroki

Koji Ito

Naoki Terasaka

Ryo Iwamura

Jun-ichiro Kita

Hitoshi Ueno

Toshihiko Ikeda

Kousuke Baba

Kazunari Tsuboike

Akiko Shima

Yukinori Kawai

Provided is a salt including a compound represented by a formula (4) and a compound represented by a formula (5). A method for producing the salt includes reacting a compound represented by a formula (2) with a compound represented by a formula (3) in the presence of a quaternary onium salt and a base to form the compound represented by the formula (4); and mixing the compound represented by the formula (4) with the compound represented by the formula (5). A method for producing a compound represented by a formula (6) includes removing, from the salt including the compounds of formulae (4) and (5), a protecting group P. In the following formulae, Pand Pare both protecting groups. 

Method for producing indoline compound

Provided is a method for producing a compound represented by a formula (6), the method comprising: a step of mixing a compound represented by a formula (4) and a compound represented by a formula (5) to form a salt consisting of the compound represented by the formula (4) and the compound represented by the formula (5); and a step of removing a protecting group Pof the salt. In the following formulae, Pis a protecting group and Pis a protecting group. 

The present invention provides a salt of a substituted pyridine compound which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a salt of a compound represented by general formula (I): wherein Ris optionally substituted alkoxy or the like.

Acid addition salt of substituted pyridine compound

The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein Ris H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

Substituted pyridine compound

The present invention discloses the compound represented by the formula (I):

N-acylamino acid amide compounds and intermediates for preparation thereof

A cyclic amine derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted of unsubstituted C.sub.1 -C.sub.8 aliphatic acyl group, a substituted or unsubstituted benzoyl group or a C.sub.1 -C.sub.4 alkoxycarbonyl group, and R.sup.3 represents a substituted 3 to 7 membered saturated cyclic amino group which may form a fused ring; or pharmaceutically acceptable salts thereof. The compounds and salts have excellent platelet aggregation inhibitory action. They are useful for the treatment and prevention of such diseases as embolism, thrombosis or arteriosclerosis and for the preparation of pharmaceutical compositions for such uses.

Cyclic amine derivatives

Growing community of inventors

Yamaguchi, Japan

Katsunori Takata