Nippon Soda Co., Ltd.

Katsunori Mikuma

Tomio Yagihara

Nobuhiro Umeda

Isami Hamamoto

Nobuo Matsui

Seiji Tazaki

Tatsumi Kobayashi

Sadafumi Yoshino

Mitsuyuki Hoshino

Shigeharu Yamazoe

Eiji Nishiwaki

Aminoacetonitrile derivatives, where the 2-position of aminoacetonitrile is optionally substituted by alkylthio groups, arylthio groups and heterocyclicthio groups. The process for making such compounds comprises reacting hydrogen cyanide with the desired corresponding R-S-H and recovering the crystallized salt thereof. The aminoacetonitrile derivatives are useful as starting materials to produce pharmaceutical and agricultural intermediates such as benzomide derivatives with fungicidal and herbicidal activities.

Aminoacetonitrile derivatives

The present invention relates to a 2,3-diaminoacrylonitrile derivative or salts thereof, having the formula ##STR1## wherein R represents an alkyl group (which may be substituted by unsubstituted or substituted phenyl groups, halogen atoms, C.sub.1-6 alkoxycarbonyl groups, carboxy groups, C.sub.1-6 alkoxycarbonyl C.sub.1-6 alkylthio groups, hydroxy groups, mercapto groups, cycloalkyl groups or heterocyclic groups containing oxygen atoms); an alkenyl group; a cycloalkyl group; an aryl group (which may be substituted by halogen atoms, C.sub.1-6 alkyl groups, nitro-groups, unsubstituted or substituted phenyl or phenoxy groups or heterocyclic groups containing oxygen atoms or sulfur atoms). The 2,3-diaminoacrylonitrile derivative can be used as starting materials for the production of pharmaceutical and/or agricultural intermediates such as cyanoimidazoles, cyanopyrazines or other cyano-substituted heterocycles.

2,3-diaminoacrylonitrile derivatives and process for making the same

A process for tetramerizing hydrogen cyanide to diaminomaleonitrile, wherein hydrogen cyanide is polymerized in an organic solvent in the presence of a basic catalyst and a cocatalyst of the group consisting of organic mercaptans and organic disulfides.

Process for the production of diaminomaleonitrile

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Kurashiki, Japan

Katsunori Mikuma