Meiji Co., Ltd.

Meiji Feed Co., Ltd.

Meiji Dairires Corporation

Katsunori Kimura

Tadao Saito

Keisuke Furuichi

Kakuhei Isawa

Yasushi Kawai

Hideaki Uchida

Makoto Yamaguchi

Yoshitaka Nakamura

Shuji Ikegami

Hiroshi Tsuboi

Naoki Taketomo

Tadashi Nakatsubo

Masaki Terahara

Noriko Kaneko

Seiko Narushima

Akinori Kume

Akina Satou

Shinya Nagafuchi

Michio Kanbe

Takenori Orihashi

Shunji Hayashi

Jun Wakabayashi

Toshihiro Sashihara

Kenji Sera

Manami Yoshida

Yoshiaki Obara

Noriaki Matsunaga

Shigeru Aizawa

Naoki Takemoto

There is provided a composition that comprises a propionic acid bacterium or a composition that comprises an oligosaccharide. The composition that comprises a propionic acid bacterium or the composition that comprises an oligosaccharide can suppress an increase of body weight of a subject by having the subject ingest the composition.

Composition containing propionibacterium freudenreichii and uses thereof

A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

Immune function modulating agents

The invention provides a composition that enhances the proliferation activity of propionic acid bacteria in the rumen of ruminants to allow the propionic acid bacteria to sufficiently exhibit their metabolic function in the rumen for the prevention and treatment of rumen acidosis in ruminants. The invention also provides use of the composition. Viable propionic acid bacteria and a lactic acid bacteria culture are orally administered to a ruminant to dramatically (rapidly) promote the proliferation of the propionic acid bacteria in the ruminant rumen, and to thereby increase the volatile fatty acid concentration in the rumen for the prevention and/or treatment of rumen acidosis in the ruminant.

Composition containing bacterium capable of producing propionic acid bacterium, and use thereof

Natural cheese which comprises a lactic acid bacterium belonging tohaving a disinfection potency against, and a method for producing the natural cheese.

[object Object]

screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discoverstrains compatible with blood groups A, B, and O.

Method for screening human ABO blood group-binding lactobacilli

The present invention provides lactic acid bacteria which are suitable for use for dietary products and pharmaceuticals, and which can suppress the increase of blood uric acid level. Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels,OLL2922, were found.

Lactic acid bacterium having effect of lowering blood uric acid level

Human ABO blood group-binding lactobacilli

Growing community of inventors

Kanagawa, Japan

Katsunori Kimura